Biological Activity
Potent and selective hCXCR6 antagonist (IC50 = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50 = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50 >79 μM).
Technical Data
| M. Wt | 502 |
| Formula | C26H32ClN3O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 60202254 |
| InChI Key | SSPYAPRDKNCABY-UHFFFAOYSA-N |
| Smiles | O=C(NC1=C(Cl)C=CC=C1)CN2[C@H]3CCC[C@@H]2C[C@](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)([H])C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 50.2 | 100 |
| ethanol | 10.04 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 502. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 1.99 mL | 9.96 mL | 19.92 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.98 mL |
| 10 mM | 0.2 mL | 1 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution. Reconstitution CalculatorReconstitution Calculator
Dilution CalculatorDilution Calculator
Calculate the dilution required to prepare a stock solution.Product Datasheets
Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Hershberger et al (2012) Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis. Probe Reports from the NIH Molecular Libraries Program PMID: 24049849
Keywords: ML 339, supplier, ML339, Potent, human, CXCR6, antagonists, antagonism, metastasis, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience
