General Information

Product

IL18RAP Antibody

Description

Affinity Purified Interleukin-18 receptor accessory protein Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Predicted:Mouse

Immunogen

Synthetic peptide taken within amino acid region 500-550 on human Interleukin-18 receptor accessory protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O95256

Overview

Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.

Molecular Function

Receptor activity

Subcellular Location

Membrane, Single-pass type I membrane protein

Expression

Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.

Structure

Belongs to the interleukin-1 receptor family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

Alternative Nomenclature

IL18RAP antibody

Accessory protein like antibody

AcPL antibody

CD218 antigen-like family member B antibody

CDw218b antibody

IL-18R-beta antibody

IL-18RAcP antibody

IL-18Rbeta antibody

IL-1R accessory protein-like antibody

IL-1R7 antibody

IL-1RAcPL antibody

IL18RAP antibody

IL18Rbeta antibody

Interleukin 18 receptor accessory protein antibody

Interleukin-1 receptor 7 antibody

Interleukin-18 receptor beta antibody