Tocris/(±)-ADX 71743/5715/50/50 mg-蚂蚁淘生物

Description: Negative allosteric modulator at mGlu₇; brain penetrant Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone Purity: ≥98% (HPLC) Biological Activity Technical Data Solubility Calculators DatasheetsReferences

Biological Activity

Negative allosteric modulator at mGlu₇ (IC₅₀ = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

Technical Data

M. Wt	269.34
Formula	C₁₇H₁₉NO₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	53391766
InChI Key	CPKZCQHJDFSOJT-UHFFFAOYSA-N
Smiles	CC(C=C1C)=CC=C1C(CC2=C3N=C(CC)O2)CC3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM Solubility

DMSO	26.93	100
ethanol	26.93	100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg

1 mM	3.71 mL	18.56 mL	37.13 mL
5 mM	0.74 mL	3.71 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDS

References

References are publications that support the products' biological activity.

Klar et al (2015) Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 35 7600 PMID: 25972184

Tassin et al (2016) Phasic and tonic mGlu₇ receptor activity modulates the thalamocortical network. Front Neural Circuits 10 31 PMID: 27199672

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