Description:PotentcathepsinKinhibitorChemicalName:N-[1-[[(Cyanomethyl)amino]carbonyl]cyclohexyl]-4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzamidePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotent,reversIBLecathepsinKinhibitor(IC50=0.25nM)thatdisplays>4000-foldselectivityovercathepsinsB,LandS.Displaysreducedselectivityincell-basedassayspossiblyduetolysosomalaccumulation.Reducescollagenbreakdownandpromotesbonedepositioninvivo.Orallyactiveandhasintrinsicfluorescence.TechnicalDataM.Wt466.6FormulaC24H30N6O2SStorageStoreat+4°CPurity≥98%(HPLC)CASNumber294623-49-7PubChemID9912381InChIKeyFIVYCSWOCXEWSE-UHFFFAOYSA-NSmilesO=C(C2=CC=C(C3=CSC(N4CCN(C)CC4)=N3)C=C2)NC1(CCCCC1)C(NCC#N)=OThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO46.66100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight466.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.14mL10.72mL21.43mL5mM0.43mL2.14mL4.29mL10mM0.21mL1.07mL2.14mL50mM0.04mL0.21mL0.43mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Palmeretal(2005)Designandsynthesisoftri-ringP3benamide-containingaminonitrilesaspotent,selective,orallyeffectiveinhibitorsofcathepsinK.J.Med.Chem.487520PMID:16302794Falgueyretetal(2005)LysosomotropismofbasiccathepsinKinhibitorscontributestoincreasedcellularpotenciesagainstoff-targetcathepsinsandreducedfunctionalselectivity.J.Med.Chem.487535PMID:16302795Desmaraisetal(2008)EffectsofcathepsinKinhibitorsbasicityoninvivooff-targetactivities.Mol.Pharmacol.73147PMID:17940194Keywords:L006235,supplier,potent,selective,cathepsin,k,inhibitors,inhibits,osteoporosis,fluroescent,fluorescence,L006235,Cathepsin,Calcium-Sensitive,Proteases,Cathepsin,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
