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R&D Systems/Human MxA/Mx1 Antibody/AF7946-SP/25 ug

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AF7946-SP-25ug

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Species ReactivityHumanSpecificityDetects human MxA/Mx1 in direct ELISAs and Western blots.SourcePolyclonal Goat IgGPurificationAntigen Affinity-purifiedImmunogenE. coli-derived recombinant human MxA/Mx1 His412-Leu630Accession # P20591FormulationLyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.LabelUnconjugated Western Blot1 µg/mLSee belowImmunohistochemistry5-15 µg/mLSee belowReconstitutionSterile PBS to a final concentration of 0.2 mg/mL.ShippingThe product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °CStability & StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.6 months, -20 to -70 °C under sterile conditions after reconstitution. Long Name:Interferon-regulated Resistance GTP-binding protein MxAEntrez Gene IDs:4599 (Human); 17857 (Mouse); 24575 (Rat)Alternate Names:human interferon-regulated resistance GTP-binding protein MXA10IFI-78Khomolog of murine (interferon-inducibleprotein p78); IFI78; IFI-78K; Mx1; MxA; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78(mouse)Background:MxA (orthoMyxovirus-resistant protein A; also IFN-induced protein p78/IFI-78K and Mx1) is a 75-78 kDa member of the Dynamin family, GTPase-binding superfamily of proteins. It is induced by type I and III interferons, and is known to reside in the cytoplasm and associate with the membranes of the ER. Typically, IFN-alphais produced when influenza virus RNA (plus other viral dsDNA and RNA) is detected by internal Pattern recognition receptors (PRRs). IFN-alphainduces the synthesis of 300+ genes, one of which is MxA (Mx1 in mouse). In primates, MxA is cytoplasmic, and interacts with the influenza virus replication cycle at a point proximal to the transcription of genomic RNA into mRNA. By contrast, Mx1 in mouse acts in the nucleus to block primary viral gene transcription. Functionally, MxA is a GTPase, but it is only the binding of GTP to MxA that is associated with antiviral activity. Nucleotide binding to MxA is also associated with nonviral activity, being associated with the potentiation of TRPC Ca2+ channel activity. Human MxA is 662 amino acids (aa) in length. It contains one GTPase domain (aa 69-340) and a GED (GTPase Effector Domain) over aa 574-662. There are two ultilized phosphorylation sites at Tyr129 and Tyr451. MxA forms homo-dimers, -tetramers and -oligomers, with multimerization suggested to be important for activity. Although IFNs are typically considered to induce Mx gene expression, HSV-1 itself also activates gene transcription. In this case, however, a truncated 54-57 kDa transcript is generated that contains an 84 aa substitution for aa 425-662. Over aa 412-630, human MxA shares 49% aa sequence identity with mouse Mx1.

R&D Systems位于美国的明尼苏达州，一直致力于生物制品的开发与生产。公司成立之初主要生产用于医院及临床应用的血控品。1997年，公司推出第一个产品--富血小板血浆质控品；1981年，公司成为全球第二家生产含血小板全血控品的供应商。40多年的发展中，R&D Systems仍持续开发各种血控品产品。

1985年，作为公司推出的第一个科研试剂产品，也是全球第一家将该产品进行商业化生产的产品，R&D Systems成功上市了TGF-beta1蛋白。作为胞外信号分子，TGF-beta1蛋白在多种细胞中进行表达，并作为胞外信号分子参与免疫功能，细胞增殖和细胞分化等生物学过程。该产品推出后，公司陆续从生物材料中纯化了几种细胞因子产品并推向市场。

天然蛋白类产品的成功推广，加速了R&D Systems在细胞因子市场的开拓。公司于1985年形成Growth Factor事业部（现Biotechnology事业部）。Biotechnology事业部的目标是生产和营销重组人细胞因子。与天然来源提取蛋白相比较，DNA重组技术生产的蛋白产品其成本更低，产量更高，完全摆脱原料的限制。1989年，Biotechnology事业部开始开发抗细胞因子的单克隆和多克隆抗体，并于1990年开发了第一个ELISA试剂盒。

2014年2月10日，R&D Systems的母公司宣布命名为Bio-Techne. Bio-Techne旗下包括R&D Systems, Novus Biologicals, BiosPacific, Tocris Bioscience, Boston Biochem和Bionostics。