产品说明
DescriptionCatalogueNumberAB2261DescriptionAnti-Tbr1AntibodyAlternateNamesT-box,brain,1BackgroundInformationTbr1geneisamemberofaconservedfamilyofgenesthatshareacommonDNA-bindingdomain,theT-box.T-boxgenesencodetranscriptionfactorsinvolvedintheregulationofdevelopmentalprocesses.Tbr1,aputativetranscriptionfactorknowntobeexpressedinpost-mitoticneurons,hasbeenfoundhighlyexpressedinglutamatergicearly-borncorticalneurons.Asimilarproteinhasbeendisruptedinmiceandshowntobecriticalforearlycorticaldevelopment,andcauseslossofprojectionneuronsintheolfactorybulbsandolfactorycortex.TheC-terminalregiontheTbr1derivedproteinwasfoundtobenecessaryandsufficientforassociationwiththeguanylatekinasedomainofcalcium/calmodulin-dependentserineproteinkinase.ProductInformationFormatAffinityPurifiedControlHumanfetalbraintissuelysatePresentationPurifiedchickenpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.StorageandShippingInformationStorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.ApplicationsApplicationAnti-Tbr1AntibodyisanantibodyagainstTbr1foruseinWB,IH.KeyApplicationsWesternBlottingImmunohistochemistryApplicationNotesImmunohistochemistryAnalysis:1:100dilutionfromapreviouslotdetectedTbr1inmousefrontalcortextissue.BIOLOGicalInformationImmunogenKLH-conjugatedlinearpeptidecorrespondingtomouseTbr1.EpitopeInternalConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.HostChickenSpecificityThisantibodyrecognizesTbr1.SpeciesReactivityHumanMouseRatHorsePigOpossumBovineCanineSpeciesReactivityNoteProventoreactwithhuman,mouse,andrat.Predictedtoreactwithhorse,pig,opossum,bovine,andcaninebasedon100%sequencehomology.AntibodyTypePolyclonalAntibodyEntrezGeneNumberNP_033348GeneSymbolTbr1T-brain-1TBR-1TES-56PurificationMethodAffinityPurfiedUniProtNumberQ64336UniProtSummaryFUNCTION:Probabletranscriptionalregulatorinvolvedindevelopmentalprocesses.TBR1isrequiredfornormalbraindevelopment.SUBCELLULARLOCATION:NucleusPotential.TISSUESPECIFICTY:Expressedinspecificlaminainthedevelopingandadultbrain.DEVELOPMENTALSTAGE:Firstdetectedaroundday10ofembryonicdevelopmentinthepreplate,atday12.5,inthecorticalplateandintermediatezone,andfromday16.5to18.5,inarostro-caudalgrADIentinthesubplate.Inthethalamus,expressionisfirstobservedatpostnatalstage,P7,andweakexpressioncontinuesinlaterpostnatalandadultstages.SEQUENCESIMILARITIES:Contains1T-boxDNA-bindingdomain.MolecularWeight~68kDaisobserved;however,UniProtKB/Swiss-ProtentryQ64336(TBR1_MOUSE)listsamassof73.941kDa.PhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。
20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。
为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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