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Novus/Recombinant Human IL-4 (CHO-expressed) Protein/10 ug/6507-IL-010
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RecombinantHumanIL-4(CHO-expressed)ProteinSummaryDetailsofFunctionalityMeasuredinacellproliferationassayusingTF‑1humanerythroleukemiccells.Kitamura,T.etal.(1989)J.CellPhysiol.140:323.TheED50forthiseffectis0.05-0.2ng/mL.SourceChineseHamsterOvarycellline,CHO-derivedhumanIL-4proteinHis25-Ser153Accession#P05112N-terminalSequenceHis25Structure/FormMonomerProtein/PeptideTypeRecombinantProteinsGeneIL4Purity>95%,bySDS-PAGEunderreducingconditionsandvisualizedbysilverstainEndotoxinNoteApplications/DilutionsTheoreticalMW15.0kDa.Disclaimernote:Theobservedmolecularweightoftheproteinmayvaryfromthelistedpredictedmolecularweightduetoposttranslationalmodifications,posttranslationcleavages,relativecharges,andotherexperimentalfactors.SDS-PAGE17-25kDa,reducingconditionsPublicationsReadPublicationsusing6507-ILinthefollowingapplications:Bioassay3publicationsPackaging,Storage&FormulationsStorageUseamanualdefrostfreezerandavoidrepeatedfreeze-thawcycles.12monthsfromdateofreceipt,-20to-70°Cassupplied.1month,2to8°Cundersterileconditionsafterreconstitution.3months,-20to-70°Cundersterileconditionsafterreconstitution.BufferLyophilizedfroma0.2μmfilteredsolutioninPBSwithBSAasacarrierprotein.Purity>95%,bySDS-PAGEunderreducingconditionsandvisualizedbysilverstainReconstitutionInstructionsReconstituteat100μg/mLinPBScontainingatleast0.1%humanorbovineserumalbumin.NotesThisproductisproducedbyandshipsfromR&DSystems,Inc.,aBio-Technebrand.AlternateNamesforRecombinantHumanIL-4(CHO-expressed)ProteinBcellgrowthfactor1BCDFB-cellstimulatoryfactor1BCGF1BCGF-1binetrakinBSF1BSF-1IL4IL-4IL-4B_cellstimulatoryfactor1interleukin4interleukin-4Lymphocytestimulatoryfactor1MGC79402pitrakinraBackgroundInterleukin-4(IL-4),alsoknownasBcell-stimulatoryfactor-1,isamonomeric,approximately13kDa‑18kDaTh2cytokinethatshowspleiotropiceffectsduringimmuneresponses(1‑3).Itisaglycosylatedpolypeptidethatcontainsthreeintrachaindisulfidebridgesandadoptsabundledfouralpha-helixstructure(4).HumanIL-4issynthesizedwitha24aasignalsequence.Alternatesplicinggeneratesanisoformwitha16aainternaldeletion.MaturehumanIL-4shares55%,39%and43%aasequenceidentitywithbovine,mouse,andratIL-4,respectively.Human,mouse,andratIL-4arespecies-specificintheiractivities(5-7).IL-4exertsitseffectsthroughtworeceptorcomplexes(8,9).ThetypeIreceptor,whichisexpressedonhematopoieticcells,isaheterodimeroftheligandbindingIL-4Ralphaandthecommongammachain(asharedsubunitofthereceptorsforIL-2,-7,-9,-15,and‑21).ThetypeIIreceptoronnonhematopoieticcellsconsistsofIL-4RalphaandIL-13Ralpha1.ThetypeIIreceptoralsotransducesIL-13mediatedsignals.IL-4isprimarilyexpressedbyTh2-biasedCD4+Tcells,mastcells,basophils,andeosinophils(1,2).Itpromotescellproliferation,survival,andimmunoglobulinclassswitchtoIgG4andIgEinhumanBcells,acquisitionoftheTh2phenotypebynaïveCD4+Tcells,primingandchemotaxisofmastcells,eosinophils,andbasophils,andtheproliferationandactivationofepithelialcells(10‑13).IL-4playsadominantroleinthedevelopmentofallergicinflammationandasthma(12,14).Benczik,M.andS.L.Gaffen(2004)Immunol.Invest.33:109.Chomarat,P.andJ.Banchereau(1998)Int.Rev.Immunol.17:1.Yokota,T.etal.(1986)Proc.Natl.Acad.Sci.83:5894.Redfield,C.etal.(1991)Biochemistry30:11029.Ramirez,F.etal.(1988)J.Immunol.Meth.221:141.Leitenberg,D.andT.L.Feldbush(1988)Cell.Immunol.111:451.Mosman,T.R.etal.(1987)J.Immunol.138:1813.Mueller,T.D.etal.(2002)Biochim.Biophys.Acta1592:237.Nelms,K.etal.(1999)Annu.Rev.Immunol.17:701.Paludan,S.R.(1998)Scand.J.Immunol.48:459.Corthay,A.(2006)Scand.J.Immunol.64:93.Ryan,J.J.etal.(2007)Crit.Rev.Immunol.27:15.Grone,A.(2002)Vet.Immunol.Immunopathol.88:1.Rosenberg,H.F.etal.(2007)J.AllergyClin.Immunol.119:1303.CustomersWhoViewedThisItemAlsoViewed...IL-2[Unconjugated]202-IL(18Reviews)(284Publications)Species:HuIFN-gamma[Unconjugated]285-IF

 

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