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Signalchem/CAMK2 alpha, Active/10 ug/C11-10G-10
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产品说明
Overview:CAMK2α is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2α is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2α can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2α fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2α increased with heightened neuronal activity (2). Gene Aliases:CAMKA; KIAA0968 Genbank Number:NM_171825 References:1.Silva, A J. et al: Impaired spatial learning in alpha-calcium calmodulin kinase II mutant mice. Science 257: 206-211, 1992.2.Thiagarajan, T C. et al: Alpha- and beta-CaMKII: inverse regulation by neuronal activity and opposing effects on synaptic strength. Neuron 36: 1103-1114, 2002.
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