Escherichia coli (E.coli) is a gram-negative, rod-shaped, facultative anerobic bacterium. Most strains of E.coli are harmless, but some are pathogenic to humans. Some pathogenic strains of E.coli produce Shiga toxins, which are potent bacteriophage encoded cytotoxins. Shiga toxin producing E.coli (STEC), including E.coli O157:H7, are a common cause of severe food poisoning in humans worldwide. Cattle and ruminants are the natural reservoir for E.coli O157:H7, where it exists in the animals’ intestine as part of the normal intestinal flora. Outside the natural host, E.coli O157:H7 can survive in diverse environments including water, soil and food. In particular, E.coli O157:H7 can survive in meat that has been contaminated with fecal matter, and undercooked beef has been identified as a major source E.coli O157 infection. The bacterium can thrive at temperatures ranging from 7- 50°C and therefore thorough cooking of meats is essential to destroy it. Other foods have been linked to E.coli O157:H7 outbreaks including unpasteurised milk, cured meats, bean sprouts and leafy vegetables, which have all been associated with fecal contamination. E.coli O157 can infect individuals from all age groups. E.coli O157:H7 is resistant to stomach acids and is highly infectious. In humans, the ingested bacterium invades and colonizes the intestinal mucosa. Symptoms of E.coli O157 infection include stomach cramps, hemorrhagic diarrhea and vomiting. Hemolytic uremic syndrome (HUS) may occur in severe cases of infection, which may result in life threatening renal failure. Pathogenic strains of E.coli acquire virulence factors through varies means including plasmids and bacteriophages. Several virulence factors have been associated with E.coli O157:H7 including shiga toxins, putative virulence plasmid O157 (pO157) and a pathogenicity island referred to as the locus of enterocyte effacement (LEE). Together these virulence factors are currently thought to be responsible for the pathogenic nature of E.coli O157:H7 (Lim JY).||Applications: |Suitable for use in Lateral Flow. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.Product Type:Mab|Isotype: IgG1|Clone No: 19D498|Host: mouse|Concentration: As reported |Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.|Purity: Purified by Protein A affinity chromatography from cell culture.|Immunogen: E. coli O157 native antigen lysate.|Specificity: Recognizes E. coli O 157. Does not react with Campylobacter coli, Campylobacter jejuni, Citobacter freundii, Clostridium difficile, E. coli O22:H8, E. coli O91:H1‐, E. coli O103:H2, E. coli O111:H21, E. coli O145:H‐, E. coli O171:H2, E. coli O174:H8, Klebriella pneumonia, Helicobacter pylori, Listeria monocytogenes, Morganella morganii, Proteus mirabilis, Salmonella enteritidis, Salmonella paratyphi, Salmonella typhi,|Salmonella typhimurium, Salmonella boydii, Shigella dysenteriae, Shigella flexneri, Shigella sonnei, Staphylococcus aureus.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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