首页 > BPS Bioscience > Bpsbioscience/PDE1B-HEK293 Recombinant Cell line/60402/2 vials

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Bpsbioscience/PDE1B-HEK293 Recombinant Cell line/60402/2 vials

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60402

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4000-520-616

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Species:HumanHostSpecies:HEK293(human)Genbank#:NM_000924Background:Phosphodiesterases(PDEs)regulatetheintracellularlevelsofcAMPandcGMPbyhydrolyzingcAMPandcGMPtotheirinactive5"monophosphates.Thesecyclicnucleotidesplayanimportantroleassecondmessengersindiversephysiologicalfunctions.PDE1Bplaysaroleinsignaltransductionbyregulatingtheintracellularconcentrationofcyclicnucleotides.PDE1BhydrolyzesbothcAMPandcGMPtonucleoside5-primemonophosphate.AlthoughitpreferscGMPatlowsubstratelevels,ithasaVmaxthatisapproximatelyequalforbothcGMPandcAMP(Polli,J.W.andKoncaid,R.L.,1994;Yu,J.etal.,1997).Description:RecombinantHEK293celllineexpressinghumanPDE1B(phosphodiesterase1B,accessionnumberNM_000924).N-terminalHis-taggedhumanPDE1BhasbeenstablyexpressedinHEK293celllineanditsexpressionwasconfirmedbyWesternblotting.ThefunctionofPDE1Bwascharacterizedbyacell-basedcGMPassay.Inthisassaysystem,cellsco-expressatrialnatriureticpeptide(ANP)receptorA(aguanylatecyclase),cyclicnucleotide5gatedcationchannelCNGA2,andthephotoproteinaequorin.IntracellularcGMPlevelismonitoredviaaequorinluminescenceinducedbyCa2+influxthroughCNGA2,actingastheintracellularcGMPsensor.UniProtQ01064Synonym(s):PDE1B,phosphodiesterase1BSuppliedAs:Eachvialcontains~1X106cellsin1mlof10%DMSO.MycoplasmaTesting:ThecelllinehasbeenscreenedusingthePCR-basedVenorGeMMycoplasmaDetectionkit(SigmaAldrich)toconfirmtheabsenceofMycoplasmaspecies.Format:aqueoussolutioncontainingDMSOInstructionsforuse:Seedatasheetfordetailedculturingandassayprotocol.Storage/StABIlity:Storeinliquidnitrogenimmediatelyuponreceipt.Application(s):UsefultomonitorcAMPandPDE1BsignalingpathwayactivityandtoscreenactivatorsorinhibitorsofPDE1B.Notes:Contactusforpricing.LicenseDisclosure:Purchaseofthiscelllinegrantsyouwitha10-yearlicensetousethiscelllineinyourimmediatelaboratory,forresearchuseonly.Thislicensedoesnotpermityoutoshare,distribute,sell,sublicense,orotherwisemakethecelllineavailableforusetootherlaboratories,departments,researchinstitutions,hospitals,universities,orbiotechcompanies.Thelicensedoesnotpermituseofthiscelllineinhumansorfortherapeuticordruguse.Thelicensedoesnotpermitmodificationofthecelllineinanyway.InappropriateuseordistributionofthiscelllinewillresultinrevocationofthelicenseandresultinanimmediateceaseofsalesanddistributionofBPSproductstoyourlaboratory.BPSdoesnotwarrantthesuitabilityofthecelllineforanyparticularuse,anddoesnotacceptanyliabilityinconnectionwiththehandlingoruseofthecellline.Modificationsofthiscellline,transfertoanotherfacility,orcommercialuseofthecellsmayrequireaseparatelicenseandadditionalfees;contactsales@bpSBIoscience.comfordetails.PublicationsusingthiscelllineshouldreferenceBPSBioscience,Inc.,SanDiego.Warning(s):Avoidfreeze/thawcyclesScientificCategory:PDEProductType:CellLineDatashownislot-specific.Contactusforspecificinformationonotherlots.

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