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Bpsbioscience/Human IL-8/90258-A/5 µg

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Species:HumanHostSpecies:E.coliMW:9kDaGenbank#:P10145a.a:23–99Background:IL-8isproducedbystimulatedmonocytesbutnotbytissuemacrophagesorT-lymphocytes.InmanycelltypesthesynthesisofIL-8isstronglystimulatedbyIL-1andTNF-alpha.Inhumanskinfibroblasts,theexpressionofIL-8isenhancedbyLeukoregulin.TheexpressionofIL-8fromrestingandstimulatedhumanbloodmonocytesisup-regulatedbyIL-7.Inchondrocytes,thesynthesisofIL-8isstimulatedbyIL1-betaTNF-alphaandbacteriallipopolysaccharides.Inhumanastrocytes,thesynthesisandsecretionofIL-8isinducedbyIL-1andTNF-alpha.TheIL-8receptor(CD128)isadimericglycoproteinconsistingofa59kDaanda67kDasubunit.ItisexpressedinmanydifferentcelltypesincludingthosenotrespondingtoIL-8.TheBIOLOGicalactivitiesofIL-8resemblethoseofarelatedprotein,NAP-2.IL-8differsfromallothercytokinesinitsABIlitytospecificallyactivateneutrophilgranulocytes.Inneutrophils,IL-8causesatransientincreaseincytosoliccalciumlevelsandthereleaseofenzymesfromgranules.IL-8alsoenhancesthemetabolismofreactiveoxygenspeciesandincreaseschemotaxisandtheenhancedexpressionofadhesionmolecules.Pre-activationbyIL-3isrequiredtorenderbasophilsandneutrophilssusceptIBLetofurtheractivationbyIL-8.NativehumanIL-8,generatedbytheproteolyticremovalofthesignalpeptideandpropeptide,hasacalculatedmolecularmassofapproximately8kDa.Description:RecombinanthumanInterleukin-8isadisulfide-linkedmonomerproteinconsistingof78aminoacidresidues,migratesasanapproximately9kDaproteinundernon-reducingandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodingHumanInterleukin-8maturechainwasexpressedinE.coli.UniProtP10145Synonym(s):IL-8,Interleukin8,CXCL8,TSG-1,IL8Purity:≥95%bySDS-PAGEandHPLCEndotoxinLevel:<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.BiologicalActivity:Activitywasdeterminedbytheabilitytochemoattracthumanpheripheralbloodmonocyteswasfoundtobeintherangeof25.0-100.0ng/ml.Formulation:Lyophilizedfroma0.2µmfilteredPBSsolution,pH7.0Format:lyophilizedproteinReconstitution:Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.Storage/Stability:Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.Reference(s):Orjalo,A.,etal.2009.Proc.Natl.Acad.Sci.106:17030-5.2.Stillie,R.M.,etal.J.Leukoc.Biol.,Sep2009,86:529-543.3.Bautista,M.V.,etal.J.Immunol.,Aug2009,183:2159-2166.Warning(s):Avoidfreeze/thawcyclesAminoAcidSequence:AVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENSScientificCategory:Cytokine/GrowthFactorsProductType:RecombinantProteinDatashownislot-specific.Contactusforspecificinformationonotherlots.

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