首页 > BPS Bioscience > Bpsbioscience/CAMK2γ, GST-tag/40042/10 µg

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Bpsbioscience/CAMK2γ, GST-tag/40042/10 µg

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40042

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Species:HumanHostSpecies:Sf9insectcellsMW:60kDaGenbank#:NM_172169Tag(s):N-terminalGST-taga.a:1–527Background:CAMK2γisamemberoftheCAMKIIfamilywhichareubiquitousserine/threonineproteinkinasesthathavebeenimplicatedindiverseeffectsofhormonesandneurotransmitters.CAMK2γhassixalternativelysplicedvariantsthatencodesixdifferentisoforms.Someofthesevariantshavebeenidentifiedinhumantumors(1).Transgenicmiceexpressingapartiallycalcium-independentmutantformofCAMKGshowed1.5-to2-foldincreaseinthethymusofthesemice,atleastinpartduetoanincreaseinthelifespanofdouble-positivethymocytes(2).TherewasanincreaseinthenumberofTcellsinthesecondarylymphoidorgansthathadacquiredanantigen-dependentmemoryphenotype.Description:RecombinanthumanCAMK2γ(C-terminaltruncation),withN-terminalGST-tag,expressedbybaculovirusinSf9cellsSynonym(s):CAMKG,CAMK,CAMK-II,MGC26678Purity:≥75%Formulation:50mMTris-HCl,pH7.5,150mMNaCl,0.25mMDTT,0.1mMEGTA,0.1mMEDTA,0.1mMPMSF,25%glycerol.Format:AqueousbuffersolutionStorage/StABIlity:>6monthsat-80°C.Application(s):Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.Reference(s):1.Tombes,R.M.etal:Identificationofnovelhumantumorcell-specificCaMK-IIvariants.Biochim.Biophys.Acta1355:281-292,1997.2.Bui,J.D.etal:AroleforCaMKIIinTcellmemory.Cell100:457-467,2000.Warning(s):Avoidfreeze/thawcyclesScientificCategory:Kinase/Serine-ThreonineProductType:RecombinantProteinDatashownislot-specific.Contactusforspecificinformationonotherlots.

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