首页 > BPS Bioscience > Bpsbioscience/NDR, GST-tag/40138/10 µg

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Bpsbioscience/NDR, GST-tag/40138/10 µg

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40138

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4000-520-616

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Species:HumanHostSpecies:Sf9insectcellsMW:81kDaGenbank#:NM_007271Tag(s):N-terminalGST-taga.a:fulllengthBackground:NDRorNuclearDbf2-relatedproteinisaserine/threoninekinaseinthesubgroupoftheAGCkinasefamilythatisregulatedbyMobproteins(1).FasandTNFαreceptorstimulationactivateshumanNDRbypromotingphosphorylationatthehydrophobicmotif.NDRactsasanovelpro-apoptotickinase,andisakeymemberoftheRASSF1A/MST1signalingcascade(2).NDRiscrucialforthefidelityofmitoticchromosomealignmentinmammaliancells.NDRisincorporatedintotheHIV-1particlesandiscleavedbytheHIV-1protease.NDR-drivencentrosomeduplicationrequiresCdk2activity,andCdk2-inducedcentrosomeamplificationisaffecteduponreductionofNDRactivity.Description:RecombinanthumanNDR,fulllength,withN-terminalGST-tag,expressedbySf9insectcellsviaabaculovirusexpressionsystem.Synonym(s):NDR1,STK38Purity:≥75%Formulation:50mMTris-HCl,pH7.5,150mMNaCl,10mMglutathione,0.1mMEDTA,0.25mMDTT,0.1mMPMSF,25%glycerol.Format:AqueousbuffersolutionStorage/StABIlity:>6monthsat-80°C.Application(s):Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.Reference(s):1.Millward,T.et.al:Molecularcloningandcharacterizationofaconservednuclearserine(threonine)proteinkinase.Proc.Nat.Acad.Sci.92:5022-5026,1995.2.VichalkovskiA.etal:NDRkinaseisactivatedbyRASSF1A/MST1inresponsetoFasreceptorstimulationandpromotesapoptosis.CurrBiol.2008Dec9;18(23):1889-95.Warning(s):Avoidfreeze/thawcyclesScientificCategory:Kinase/Serine-ThreonineProductType:RecombinantProteinDatashownislot-specific.Contactusforspecificinformationonotherlots.

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