产品说明
DescriptionATG16L1playsanessentialroleinautophagy.ItisahomooligomerantinteractswithATG5.Partofeithertheminorandmajorcomplexesrespectivelycomposedof4setsofATG12-ATG5andATG16L1(400kDa)or8setsofATG12-ATG5andATG16L1(800kDa).APG16L1localisestothecytoplasm,inparticularlytopreautophagosomalstructure(PAS)whereitisinvolvedinthemembranetargetingofATG5.Thereare5namedisoformsproducedbyalternativesplicing.GeneticvariationwithinATG16L1areassociatedwithsusceptibilitytoinflammatoryboweldiseasetype1.BatchNo.SeeproductlabelUnitsize100µlAntigenN-terminalofhumanATG16-L1proteinconjugatedtoBlueCarrierProteinhasbeenusedastheimmunogen.OtherNamesAutophagy-relatedprotein16-1;APG16-like1;ATG16L1AccessionA16L1_HUMANProducedinRabbitPurityWholeserumApplicationsNon-reducedwesternblot:1:100;IP:1-50-1:100(5-10uL/500uLlysate);ELISA:1:2000-1:3000directdetectiononly,recombinantimmunogen.SpecificityDetectshumanproteinvianon-reducedWB,andELISACross-reactivityHuman,rat.Otherspeciesnotyettested.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.ExpiryDateSixmonthsafterpurchaseSpecificReferences1.CooneyRetal(2009).NOD2stimulationinducesautophagyindendriticcellsinfluencingbacterialhandlingandantigenpresentation.Nat.Med.Dec620092.ScharlM.etal(2011).Proteintyrosinephosphatasenonreceptortype2regulatesautophagosomeformationinhumanintestinalcells.InflammBowelDis.2011Oct10.References1.ZhengH,etal.DNASeq.15:303-305(2004).2.ClarkH.F,etal.GenomeRes.13:2265-2270(2003).
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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