Catalogue numberPRO-2078 SynonymsMYC Induced Nuclear Antigen, MINA53, MDIG, 60S RibosomalProtein L27a Histidine Hydroxylase, Mineral Dust-Induced Gene Protein, HistoneLysine Demethylase MINA Ribosomal Oxygenase MINA, Nucleolar Protein 52, NO52, ROX,Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase MINA, Myc-InducedNuclear Antigen, 53 KDa, Mineral Dust Induced Gene Protein, MYC-Induced NuclearAntigen, EC 1.14.11.-, Bifunctional lysine-specific demethylase andhistidyl-hydroxylase MINA.IntroductionMYC Induced Nuclear Antigen, also known as MINA is an oxygenase whichcan function both as a histone lysine demethylase and a ribosomal histidine hydroxylase. MINA is involved in the demethylation of trimethylatedLys-9 on histone H3 (H3K9me3), leading to an increase in ribosomal RNAexpression. MINA also catalyzes thehydroxylation of 60S ribosomal protein L27a on His-39. In addition, MINA plays a significant role in cell growth andsurvival.MINA is implicated in ribosomebiogenesis, probably in the duration of the assembly process of pre-ribosomalparticles.DescriptionMINA Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 485 amino acids (1-465 a.a) andhaving a molecular mass of 54.9kDa.MINA is fused to a 20 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.SourceEscherichia Coli.Physical AppearanceSterile Filtered clear solution.FormulationMINA protein solution (0.25mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.PurityGreater than 90.0% as determined by SDS-PAGE.Amino acid sequenceMGSSHHHHHH SSGLVPRGSHMPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK TETFFKEFWE QKPLLIQRDD PALATYYGSLFKLTDLKSLC SRGMYYGRDV NVCRCVNGKK KVLNKDGKAH FLQLRKDFDQ KRATIQFHQP QRFKDELWRIQEKLECYFGSLVGSNVYITP AGSQGLPPHY DDVEVFILQL EGEKHWRLYH PTVPLAREYSVEAEERIGRP VHEFMLKPGD LLYFPRGTIH QADTPAGLAH STHVTISTYQ NNSWGDFLLD TISGLVFDTAKEDVELRTGI PRQLLLQVES TTVATRRLSG FLRTLADRLE GTKELLSSDM KKDFIMHRLPPYSAGDGAEL STPGGKLPRLDSVVRLQFKD HIVLTVLPDQ DQSDETQEKM VYIYHSLKNS RETHMMGNEE ETEFHGLRFP LSHLDALKQI WNSPAISVKDLKLTTDEEKE SLVLSLWTEC LIQVV.Safety Data SheetSDSUsageProspec"s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec-Tany TechnoGene Ltd.公司创立人Dr. Tanchum (Tany) Amarant 主要致力于蛋白生物化学方面的研究工作，1947年出生于以色列。1991-1997创建ReProGen 公司，从事细胞因子和趋化因子的大量生产及纯化；1997-2000创建ProSpec-TechnoGene，主要生产用于生命科学研究的各种重组蛋白及相关抗体。拥有专利United States Patent 5434135。
ProSpec is an evolving biotech company providing highly purified proteins worldwide which serve the research community with cytokine-related products for cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cell research.
Among our proteins are Interferons, Interleukins, Bone Morphogenic Proteins, Tumor Necrosis factors, Leptins, Stem Cell factors, Prolactins, Chemokines, Antibodies, Peptides, Enzymes, Viral Antigens, various growth factors such as: Platelet Derived, Epidermal, Insulin Like, Nerve, Connective Tissue, Vascular Endothelial, Fibroblast and more.....
Our research team and scientists have been able to assemble more than 1700 recombinant proteins, peptides and antibodies for your research needs. The proteins are rigorously tested to meet the research and development demand for excellent quality, uncompromising biological activity at competitive prices.
ProSpec has established sterling reputation among the scientific community, a reputation built on innovative products, customer service and attention to detail. Our reputation for quality is an essential factor in achieving a favorable position in the market place and the benefits associated with manufacturing top quality products.
