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StressMarq/Anti-ABCG2 Antibody/SPC-1317D-A700/100-µl
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Overview:ProductNameABCG2AntibodyDescriptionRabbitAnti-HumanABCG2PolyclonalSpeciesReactivityHumanApplicationsWB,IHCAntibodyDilutionWB(1:2000),IHC(1:200);optimaldilutionsforassaysshouldbedeterminedbytheuser.HostSpeciesRabbitImmunogenSpeciesHumanImmunogenAsynthesizedpeptidederivedfromhumanABCG2ConjugatesAlkalinePhosphatase,APC,ATTO390,ATTO488,ATTO565,ATTO594,ATTO633,ATTO655,ATTO680,ATTO700,Biotin,FITC,HRP,PE/ATTO594,PerCP,RPE,Streptavidin,UnconjugatedPropertiesStorageBufferPBSpH7.4,50%glycerol,150mMNaCl,0.02%sodiumazideStorageTemperature-20ºCShippingTemperatureBlueIceor4ºCPurificationAffinityPurifiedClonalityPolyclonalIsotypeIgGSpecificityDetectsendogenouslevelsoftotalABCG2CiteThisProductStressMarqBiosciencesCat#SPC-1317,RRID:AB_2713493CertificateofAnalysisA1:1000dilutionofSPC-1317wassufficientfordetectionofABCG2in10µgofmousekidneycelllyatesbyECLimmunoblotanalysisusingGoatAnti-RabbitIgG:HRPasthesecondaryantibody.BIOLOGicalDescriptionAlternativeNamesABCtransporterantibodyABC15antibodyABCG2antibodyABCG2antibodyABCG2_HUMANantibodyABCPantibodyATPbindingcassettesubfamilyG(WHITE)member2antibodyATPbindingcassettetransporterG2antibodyATP-bindingcassettesub-familyGmember2antibodyBCRPantibodyBCRP1antibodyBMDPantibodyBreastcancerresistanceproteinantibodyCD338antibodyCDw338antibodyCDw338antigenantibodyEST157481antibodyGOUT1antibodyMGC102821antibodyMitoxantroneresistanceassociatedproteinantibodyMitoxantroneresistance-associatedproteinantibodyMRXantibodyMultidrugresistanceeffluxtransportATPbindingcassettesubfamilyG(WHITE)member2antibodyMXRantibodyMXR1antibodyPlacentaspecificATPbindingcassettetransporterantibodyPlacentaspecificMDRproteinantibodyPlacenta-specificATP-bindingcassettetransporterantibodyUAQTL1antibodyCellularLocalizationCellmembrane,MitochondrionmembraneAccessionNumberNP_004818.2GeneID9429SwissProtQ9UNQ0ScientificBackgroundABCG2(BCRP1/ABCP/MXR)isamemberoftheATP-bindingcassettetransporterfamilythatfunctionsasATP-dependenttransportersforawidevarietyofchemicalcompoundsandareassociatedwithdrug-resistanceincancercells.ABCG2isaheavilyglycosylatedtransmembraneproteinwithsixtransmembranespanningregionsconsistentwithitfunctioningasahalf-transporter.TheABCfamilycanexistaseitherfull-lengthtransportersorashalf-transportersthatformfunctionaltransportersthroughhomo-orheterodimerization.Originallythoughttoplayaroleindrugresistanceduetoitsresistancetoanumberofchemotherapeuticdrugs,ABCG2hasalsobeenfoundinthekidney,andstemcellpopulations.StudiesalsosuggestthatitcanbeusedasacellsurfaceMarkertoidentifyhematopoieticstemcellswithinthebonemarrowfractionoflineagenegativecells.TheexpressionofABCG2appearsgreatestonCD34-cellsandisdownregulatedwiththeacquisitionofCD34onthecellsurface.References1.ZhouS.,etal.(2001)Nat.Medicine.7:1028.2.DoyleL.A.andRossD.D.(2003)Oncogene.22:7340-58.3.AllenJ.D.etal.(1999)CancerRes.59:4237-41.4.DoyleL.A.,etal.(1998)ProcNatlAcadSciUSA.95:15665-70.5.AllikmetsR.,etal.(1998)CancerRes.58:5337-9.6.MiyakeK.,etal.(1999)CancerRes.59:8-13.7.RobeyR.W.,etal.(2001)ClinCancerRes.7:145-52.ZhouS.,etal.(2001)Nat.Medicine.7:1028.ProductImagesCurrentlytherearenoimagesforthisproductProductCitations(0)Currentlytherearenocitationsforthisproduct. ATTO700Overview:HighfluorescenceyieldExcellentthermalandphotostABIlityQuenchedbyelectrondonorsVeryhydrophilicGoodsolubilityinpolarsolventsZwitterionicdyeMolarMass:575g/molATTO700Datasheet OpticalProperties:λex =700 nmλem=719nmεmax=1.25×105Φf= 0.25τfl =1.6nsBrightness= 31.3Laser =676nmFilterset =Cy®5.5
StressMarq Biosciences公司的核心技术领域为细胞应激与离子通道以及载体研究,同时在其他领域也取得了一定成就,包括翻译后修饰,提供甲基化与乙酰基化抗体。其中,细胞应激领域主要包括热休克蛋白(HSP)领域。我们公司不仅在热休克蛋白领域领先全球,而且在氧化应激领域也卓有成就。StressMarq的优势在于提供四种独立的产品系列,分别涉及抗体、蛋白、酶联免疫吸附试验(ELISA)试剂盒及小分子领域。
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