OVERVIEW: Synonyms Monoclonal PAPPA antibody, Anti-PAPPA antibody, Anti PAPPA antibody, PAPPA antibody, PAPP-A antibody, Pregnancy Associated Plasma Protein A antibody, PAPP A antibody, Pregnancy Associated Plasma Protein A antibody, PAPP-A antibody, PAPP A antibody Specificity Human Applications ELISA, IP, WB Immunogen PAPPA antibody was raised in mouse using purified human PAPP-A/proMBP complex or purified human atherosclerotic tissue form of PAPP-A as the immunogen. Assay Information 10-P66A can be used in a sandwich immunoassay as a coating antibody in conjunction with 10-7954 as the conjugate antibody SPECIFICATIONS: Host Mouse Clone M998311 Isotype IgG2b Method of Purification PAPPA antibody was purified by chromatography on protein A Sepharose. Form & Buffer Protein A purified and supplied in PBS, pH 7.4, 0.1 % NaN3. STORAGE & SAFETY: Storage Store at 4 deg C. Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. GENERAL INFORMATION: Biological Significance Pregnancy-associated plasma protein A, pappalysin 1, also known as PAPPA, is a protein used in screening tests for Down syndrome. PAPPA is a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses