产品说明
Antibody Target
TRAF6
Host
Rabbit
Antibody Type
Polyclonal
Isotype
Rabbit IgG
Immunogen
Synthetic peptide surrounding amino acid 436 of rat TRAF6
Accession #
NP_001101224
Gene ID
311245
Appearance
Colorless liquid
Concentration
0.5 mg/ml
Formulation
100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification
Affinity purified
Species Reactivity
Human, mouse, rat
Application
Western blot
Application & Usage
Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 54 kDa TRAF6 in samples of human and mouse origins. Reactivity to other species has not been tested.
Handling
The antibody solution should be gently mixed before use.
Storage Conditions
-20 °C
Shipping Conditions
Gel Pack
USAGE
For Research Use Only! Not For Use in Humans.
Description:TRAFs (TNF receptor associated proteins) form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). Recently it has been shown that TRANCE/OPGL activates the antiapoptotic serine/threonine kinase Akt/PKB throμgh a signaling complex involving c-Src and TRAF6. Mice deficient in TRAF6 are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function. Like TRAF2 and TRAF3, TRAF6 is also essential for perinatal and postnatal survival. These findings establish diverse and critical roles for TRAF6 in perinatal and postnatal survival, bone metabolism, LPS, and cytokine signaling.
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