首页 > NSJ Bio > NSJ Bio/Keratin 8 Antibody / Cytokeratin 8 [clone 3G9] (RQ4889)/100 ug/RQ4889

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NSJ Bio/Keratin 8 Antibody / Cytokeratin 8 [clone 3G9] (RQ4889)/100 ug/RQ4889

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RQ4889

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DescriptionKeratin, type II cytoskeletal 8, also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.Application NotesOptimal dilution of the Keratin 8 antibody should be determined by the researcher.ImmunogenAmino acids D107-K325 from the human protein were used as the immunogen for the Keratin 8 antibody.StorageAfter reconstitution, the Keratin 8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. Related Products1. View all Keratin 8 antibodies

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