首页 > NSJ Bio > NSJ Bio/Anti-ACTH Antibody / Synacthen [clone SPM333] (V9067)/20 ug/V9067-20UG

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NSJ Bio/Anti-ACTH Antibody / Synacthen [clone SPM333] (V9067)/20 ug/V9067-20UG

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V9067-20UG

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NSJ Bio

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DescriptionACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.Application NotesThe optimal dilution of the anti-ACTH antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.ImmunogenAmino acids 1-24 of the human protein were used as the immunogen for this anti-ACTH antibody.StorageStore the anti-ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). Related Products1. View all ACTH antibodies

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