首页 > NSJ Bio > NSJ Bio/Anti-CD74 Antibody [clone SPM523] (V9108)/100 ug/V9108SAF-100UG

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NSJ Bio/Anti-CD74 Antibody [clone SPM523] (V9108)/100 ug/V9108SAF-100UG

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V9108SAF-100UG

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NSJ Bio

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DescriptionCD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).Application NotesThe optimal dilution of the anti-CD74 antibody for each application should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.ImmunogenSU-DHL-4 lymphoma cells were used as the immunogen for this anti-CD74 antibody.StorageStore the anti-CD74 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). Related Products1. View all CD74 antibodies

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