首页 > NSJ Bio > NSJ Bio/Anti-IgA Antibody [clone IA761] (V2619)/100 ug/V2619SAF-100UG

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NSJ Bio/Anti-IgA Antibody [clone IA761] (V2619)/100 ug/V2619SAF-100UG

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V2619SAF-100UG

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NSJ Bio

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DescriptionThis mAb is specific to heavy chain of IgA and shows minimal cross-reaction with heavy chains of other immunoglobulins. It is reactive with all subclasses of Alpha heavy chain. Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through inter-chain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin A (IgA) is the main protein of the mucosal immune system. It is generated by B-cells in gut-associated lymphoid tissues. Daily production of IgA exceeds that of any of the other immunoglobulins. IgA exists mainly in dimers but can also exist as polymers or as monomers. Dimers and polymers contain a joining (J) chain that can be bound by the polymeric immunoglobulin receptor (pIgR) for transportation of the molecule to mucosal surfaces. The most common feature of plasmacytomas, and certain non-Hodgkin s lymphomas is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.Application NotesOptimal dilution of the Anti-IgA antibody should be determined by the researcher.1. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minImmunogenPurified human immunoglobulin alpha heavy chain was used as the immunogen for the Anti-IgA antibody.StorageStore the Anti-IgA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). Related Products1. View all human IgA antibodies

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