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NSJ Bio/HAS1 Antibody (F48932)/0.08 ml/F48932-0.08ML
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DescriptionHyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.Application NotesTitration of the HAS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenA portion of amino acids 166-193 from the human protein was used as the immunogen for this HAS1 antibody.StorageAliquot the HAS1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles. Related Products1. View all HAS1 antibodies
NSJ Bioreagents已有20多年的历史。 NSJ Bio提供领先的、广泛使用的单克隆抗体以及单克隆和多克隆抗体的所有领域的研究,包括肿瘤,肿瘤生物标志物,细胞凋亡,免疫学,细胞生物学和转录因子。产品提供多种规格,以更好地适应研究人员的测试需求和预算限制。
 
链接:http://www.nsjbio.com/
温馨提示:不可用于临床治疗。

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