首页 > NSJ Bio > NSJ Bio/Lamin A/C Antibody (R30269)/100 ug/R30269

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NSJ Bio/Lamin A/C Antibody (R30269)/100 ug/R30269

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R30269

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DescriptionLamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The Lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Protein deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.Application NotesThe stated application concentrations are suggested starting points.Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAmino acids 455-469 (RNKSNEDQSMGNWQI) were used as the immunogen for this Lamin A/C antibody (100% homologous in human, mouse and rat).StorageAfter reconstitution, the Lamin A/C antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.Related Products1. View all Lamin antibodies2. View all Lamin A/C antibodies

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