首页 > NSJ Bio > NSJ Bio/LOX-1 Antibody / OLR1 (R30931)/100 ug/R30931

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NSJ Bio/LOX-1 Antibody / OLR1 (R30931)/100 ug/R30931

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DescriptionOLR1 (oxidized low density lipoprotein (lectin-like) receptor 1), also called CLEC8A and LOX-1 (Lectin type oxidized LDL receptor 1), is a receptor which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL). The OLR1 gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on OLR1/LOX-1 expression, but incubation with OxLDL resulted in a dose-dependent increase in mRNA and protein expression.LOX-1 is expressed in macrophages, but not in vascular smooth muscle cells, suggesting a role for the receptor in the pathophysiology of atherosclerotic cardiovascular disease.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the LOX-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAn amino acid sequence from the middle region of human LOX-1/OLR1 (NEKSKEQMELHHQN) was used as the immunogen for this LOX-1 antibody.StorageAfter reconstitution, the LOX-1 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all LOX-1 antibodies

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