首页 > NSJ Bio > NSJ Bio/MAG Antibody (R30843)/100 ug/R30843

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NSJ Bio/MAG Antibody (R30843)/100 ug/R30843

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R30843

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DescriptionMyelin-associated glycoprotein, also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is though to be involved in the process of myelination. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. Resistant embryonic neurons were rendered sensitive by expression of NgR. The glycoprotein binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with the glycoprotein prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney (HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation.Application NotesThe stated application concentrations are suggested starting points.Titration of the MAG antibody may be required due to differences in protocols and secondary/substrate sensitivity.1. MAG is seen in western blotting from 60~100KD depending on the level of glycosylation.ImmunogenAmino acids 114-132 (KYYFRGDLGGYNQYTFSEH) were used as the immunogen for this MAG antibody (100% homologous in human, mouse and rat).StorageAfter reconstitution, the MAG antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all MAG antibodies

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