首页 > NSJ Bio > NSJ Bio/Myogenin Antibody Cocktail [clone MGN185 + F5D] (V3139)/20 ug/V3139-20UG

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NSJ Bio/Myogenin Antibody Cocktail [clone MGN185 + F5D] (V3139)/20 ug/V3139-20UG

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V3139-20UG

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NSJ Bio

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DescriptionMyogenin is a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors that also includes MyoD, Myf-5, and MRF4 (also known as herculinor Myf-6). MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs. Anti-myogenin labels the nuclei of myoblasts in developing muscle tissue, and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas. Positive nuclear staining may occur in Wilms tumor.Application NotesThe optimal dilution of the Myogenin antibody for each application should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.ImmunogenFull length human recombinant protein (MGN185) and a partial rat recombinant protein (amino acid 30-224) (F5D) were used as the immunogens for this Myogenin antibody cocktail.StorageStore the Myogenin antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). Related Products1. View all Myogenin antibodies

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