首页 > NSJ Bio > NSJ Bio/NM23 Antibody (R30927)/100 ug/R30927

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NSJ Bio/NM23 Antibody (R30927)/100 ug/R30927

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R30927

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DescriptionNME1 (NME/NM23 nucleoside diphosphate kinase 1), also called non-Metastatic protein 23 (NM23), is an enzyme that in humans encoded by the NME1 gene. The promoters of the mouse and human NME1 genes, like those of other NME genes, contain several binding sites for AP2, NF1, Sp1, LEF1, and response elements to glucocorticoid receptors.Immunofluorescence microscopy demonstrated colocalization of NME1 in nuclei of B cells expressing EBNA3C. Expression of EBNA3C reversed the ability of NME1 to inhibit migration of BL and breast carcinoma cells. NME1/NM23 bound SET and was released from inhibition by GZMA cleavage of SET. After GZMA loading or cytotoxic T lymphocyte attack, SET and NM23 translocated to the nucleus and SET was degraded, allowing NM23 to nick chromosomal DNA. Using a Drosophila model system,Dammai et al.(2003) showed that the Drosophila NME1 homolog, AWD, regulates trachea cell motility by modulating FGFR levels through a dynamin -mediated pathway.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the NM23 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAn amino acid sequence from the C-terminus of human NM23 (EELVDYTSCAQNWIYE) was used as the immunogen for this NM23 antibody.StorageAfter reconstitution, the NM23 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all NM23 antibodies

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