首页 > BioGems > BioGems/Recombinant Human ApoE2/100µg/350-12-100µg

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BioGems/Recombinant Human ApoE2/100µg/350-12-100µg

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350-12-100µg

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BioGems

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DescriptionApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism.In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism.Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ.ApoE is an important constituent of all plasma lipoproteins.It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism.It also binds with the LDL receptor (apo B/E).Defects in ApoE are a cause of hyperlipoproteinemia type III.ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution.Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity.E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels.Recombinant human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

2014年PeproTech公司推出自己的流式细胞术产品品牌，即BioGems。BioGems意为生物钻石，其产品涵盖多种荧光标记的流式抗体、具有生物活性的功能性抗体，以及流式细胞术辅助试剂，如溶血剂和破膜剂等。BioGems产品全部在美国生产，相信其优异的品质和低于其它国际流式厂商的价位将能为广大用户提供更好的选择。