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FabGennix/EDG8 Antibody/S1P5R-501AP
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Descriptionbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.FollowedHyperlink { text-decoration:underline; color:#800080 }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductEDG8 AntibodyDescriptionAffinity Purified Sphingosine 1-phosphate receptor 5 Antibody Verified ApplicationsELISA, WBHostRabbitSpecies Cross ReactivityHuman, Mouse, RatImmunogenSynthetic peptide taken within amino acid region 380-400ofrat S1P5R/EDG8protein.SpecificityDoes not cross eact to other Spingosine 1-phosphate receptor subtypes. Labels a strong band of EDG8 of 48-50 kDa. Also labels a 54 kDa band, the identity of this is not known but may represent phosphorylated EDG8.Physical PropertiesQuantity100 µgVolume200 µlConcentration0.52-0.63 µg/µl in antibody stabilization bufferFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolDB1:10,000ELISA1:10,000Western Blot1:500ProteinUniprot #Q9JKM5OverviewReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins.Molecular FunctionG-protein coupled receptor, Receptor, TransducerSubcellular LocationCell membrane; Multi-pass membrane proteinExpressionFound almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts ofAlternative NomenclatureEDG 8 antibodyEndothelial differentiation G protein coupled receptor 8 antibodyEndothelial differentiation sphingolipid G protein coupled receptor 8 antibodyS1P receptor 5 antibodyS1P receptor Edg 8 antibodySphingosine 1 Phosphate Receptor 5 antibodySphingosine 1-phosphate receptor Edg-8 antibodySPPR2 antibodyProtein information supplied by UniProt

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