DescriptionSpecification Sheetbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductTrkA AntibodyDescriptionAffinity Purified Tyrosine Receptor Kinase A Antibody Verified ApplicationsELISA, IHC, IP, WBHostChickenSpecies Cross ReactivityHuman, Mouse, RatImmunogenSynthetic peptide taken within amino acid region 360-410 on human TrkA protein.Accession #GenBank: BAA34355.1Physical PropertiesQuantity100 µgVolume200 µlConcentration0.6 µg/µl in antibody stabilization bufferImmunoglobulinIgYFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolELISA1:10,000Immunoprecipitation1:200Immunohistochemistry1:100Western Blot1:500ProteinUniprot #P04629OverviewReceptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.Molecular FunctionDevelopmental Protein; Kinase; Receptor; Transferase; Tyrosine-protein kinaseSubcellular LocationCell membrane; Single-pass type I membrane protein; Early & Late endosome membraneExpressionIsoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.StructureBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.Alternative NomenclatureCIPA antibodygp140trk antibodyHigh affinity nerve growth factor receptor antibodyMTC antibodyNeurotrophic tyrosine kinase receptor type 1 antibodyNtrk1 antibodyOncogene TRK antibodyp140-TrkA antibodySlow nerve growth antibodyTRK antibodyTrk-A antibodyTRK1 antibodyTRK1-transforming tyrosine kinase protein antibodyTropomyosin-related kinase A antibodyTyrosine kinase receptor A antibodyProtein information supplied by UniProtTo view the Specification Sheet for TrkAAntibody, please click the link below:TrkA Antibody | FabGennix

苏州蚂蚁淘Fabgennix授权代理业务。Fabgennix授权代理， Fabgennix北京代理， Fabgennix华东代理，Fabgennix华北代理，Fabgennix华中代理，Fabgennix华南代理。

Fabgennix
我们提供高质量的研究工具，专家技术支持，相关的准确数据以及快速的全球运输。我们不断在我们的库存中添加新产品，包括一级和二级抗体，试剂，试剂盒，多肽和阳性对照。我们所有的抗体都在内部开发和表征。我们为我们的Single Source Antibodies™感到自豪。

部分产品的详细列表：Fabgennix授权代理

货号	产品	价格
FGI-1989	StripOBuffer Western Blot Stripping Buffer	$150.00
HRP-1060	Rabbit Anti-Chicken IgG HRP	$150.00
FGI-1943	SolObuffer Cell Lysis Kit	$175.00
FGI-1963	DiluOBuffer - Antibody Dilution Buffer	$185.00
HIL2-E96.1	Human IL-2 ELISA Kit	$495.00