首页 > GenWay > GenWay/Schistosoma mansoni IgG (Bilharziosis)/GWB-7A2555/1x96 Assays

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GenWay/Schistosoma mansoni IgG (Bilharziosis)/GWB-7A2555/1x96 Assays

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GWB-7A2555

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Description:PleaseclickhereforMSDSPDFDatasheetProductName:SchistosomamansoniIgGELISA#ofSamples:1x96AssaysIntendedUse:TheSchistosomamansoniIgG-ELISAisintendedforthequalitativedeterminationofIgGclassantibodiesagainstSchistosomamansoniinhumanserumorplasma(citrate).Introduction:Schistosomesbelongtotheclassofdistomas(trematodes).Theyrankamongthemostfrequentpathogens.Estimationsoriginateinmorethan200millionaffectedpeople.Thematureparasitesare622mmlong.ThemostimportantspeciesareSchistosomamansoni,S.japonicumandS.haematobium.SchistosomamansoniiscommoninAfrica,SouthAmericaandMiddleEast.Schistosomiasis(bilharziosis)isdependingonspeciesandlocationoftheparasitesadiseaseoftheintestine,liverandspleenresp.urinarypassages.Humansare(re)infectedbycontactwithfreshwaterwhichiscontaminatedbyovacontainingurineorfaeces.Iflarvaeboreintohumanskin,firstatransientskinreactionappears(itchwithexanthemaorerythema,byrepeatedlyinfectioncercarialdermatitisispossIBLe).After3-10weeksthemeanwhilesexuallymaturewormssynthesizecytotoxicandallergicsubstanceswhichcoursefeverishreactioninhumans(Katayamafever).Theinfectedpersonismostlyharmedbytheeggs,whichgetintoorgansviabloodexcretingproteinsandglycoproteins.Thepersonreactsunderparticipationofownantibodiesandimmunecomplexeswithformationofgranulomaandgranulomatousproliferationinintestineandurinarybladdermucosa.Notexcretedeggsdieafter3weeksandwillbedissolvedorcalcified.Theaffectedtissuegetsfibrous.Infinalstagebilharziosiswillcausedead.Principlesoftheassay:ThequalitativeimmunoenzymaticdeterminationofIgG-classantibodiesagainstSchistosomamansoniisbasedontheELISA(Enzyme-linkedImmunosorbentAssay)technique.MicrotiterstripwellsareprecoatedwithSchistosomamansoniantigenstobindcorrespondingantibodiesofthespecimen.AfterwashingthewellstoremoveallunboundsamplematerialhorserADIshperoxidase(HRP)labelledProteinAconjugateisadded.Thisconjugatebindstoantigen-antibodycomplexes.TheimmunecomplexformedbytheboundconjugateisvisualizedbyaddingTetramethylbenzidine(TMB)substratewhichgivesabluereactionproduct.TheintensityofthisproductisproportionaltotheamountofSchistosoma-specificIgGantibodiesinthespecimen.Sulphuricacidisaddedtostopthereaction.Thisproducesayellowendpointcolour.Absorbanceat450nmisreadusinganELISAmicrowellplatereader.StorageandStABIlity:Thereagentsarestableuptotheexpirydatestatedonthelabelwhenstoredat2...8°C.LimitationsoftheTest:Bacterialcontaminationorrepeatedfreeze-thawcyclesofthespecimenmayaffecttheabsorbancevalues.Diagnosisofaninfectiousdiseaseshouldnotbeestablishedonthebasisofasingletestresult.Aprecisediagnosisshouldtakeintoconsiderationclinicalhistory,symptomatologyaswellasSEROlogicaldata.Inimmunocompromisedpatientsandnewbornsserologicaldataonlyhaverestrictedvalue.ReferencesBurkhardt,F.[Hrsg.]:MikroBIOLOGischeDiagnostik.Thieme,Stuttgart,NewYork1992.9-452Hahn;Falke;Kaufmann;Ullmann[Hrsg.]:MedizinischeMikrobiologieundInfektiologie.Springer,Berlin,Heidelberg32001.784ff.Jordan,P.;WebbeG.;Sturrock,F.:Humanschistosomiasis.CABInternational,WallingfordOxon1993.Lang,W.;Löscher,T.[Hrsg.]:In:TropenmedizininKlinikundPraxis.Thieme,Stuttgart,NewYork2000.9-204http://www.rki.de/INFEKT/STECKBRF/STBR_PA/PARASIT.HTM?/INFEKT/STECKBRF/STBR_PA/SCHISTO.HTM&1AdditionalInformation:NameSchistosomamansoniIgG(Bilharziosis)RelatedProductNamesSchistosomamansoniIgG–ELISAMolecularWeight0.5StorageThereagentsarestableuptotheexpirydatestatedonthelabelwhenstoredat2...8°C.IntendedUseResearchUseOnly

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