首页 > Hycult Biotech > Hycult Biotech/C3a/C3a des Arg, Human, mAb 2991, immuno assay antibody/HM2074-IA/0.5 mg

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Hycult Biotech/C3a/C3a des Arg, Human, mAb 2991, immuno assay antibody/HM2074-IA/0.5 mg

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HM2074-IA

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Description:C3a/C3adesArg,Human,mAb2991,immunoassayantibodyThemonoclonalantibody2991recognizestheneo-epitopeofhumanC3a/C3a-desArgthatisformeduponcleavageofthecomplementproteinC3intoC3aandC3b.Thecomplementsystemisanimportantpartofthehumoralresponseininnateimmunity,consistingofthreedifferentpathways.Thethirdcomplementcomponent,C3,iscentraltotheclassical,alternativeandlectinpathwaysofcomplementactivation.Activationproductsofthecomplementcascadecontainneo-epitopesthatarenotpresentintheindividualnativecomponents.Monoclonalantibodiesdetectingneo-epitopeshavebeenusedfordirectquantificationofactivationatdifferentstepsinthecomplementcascade.ThesynthesisofC3istissue-specificandismodulatedinresponsetoavarietyofstimulatoryagents.C3isthemostabundantproteinofthecomplementsystemwithserumproteinlevelsofabout1.3mg/ml.AninheriteddeficiencyofC3predisposesthepersontofrequentassaultsofbacterialinfections.Inulcerativecolitis,andidiopathicchronicinflammatoryboweldisease,thedepositionofC3inthediseasedmucosahasbeenreported.ProteolysisbycertainenzymesresultsinthecleavageofC3releasingC3aanaphylatoxinandC3b.C3aisaproteinof74aminoacids.C3aitselfisveryshort-livedandinserumiscleavedrapidlyintothemorestableC3a-desArg(alsocalledacylationstimulatingprotein,ASP).Therefore,measurementofC3a-desArgallowsreliableconclusionsaboutthelevelofcomplementactivationinthetestsamples.C3aisamediatoroflocalinflammatoryprocesses.Itinducessmoothmusclecontraction,increasesvascularpermeABIlity,andcauseshistaminereleasefrommastcellsandbasophilicleukocytes.C3aisinvolvedininflammatoryreactionsseeningram-negativebacterialsepsis,trauma,ischemicheartdisease,post-dialysissyndromeandavarietyofautoimmunediseases.Normalvaluesinplasmaofcontrolpersonsrangebetween48150ng/ml(median:86.4ng/ml,SD:29.3ng/ml)Monoclonalantibody2991recognizesbothC3aandC3a-desArg,withatleasta5xhigherpreferenceforC3a-desArg.Specifications:CatalognumberHM2074-IAProducttypeMonoclonalantibodiesQuantity0.5mgFormulation0.5mgof0.2μmfilteredproteinGpurifiedantibodysolutioninPBSwithaconcentrationofatleast0.5mg/ml(exactconcentrationisindicatedonthelabel).ApplicationImmunoassays,WesternblotApplicationNotesW:AreducedsampletreatmentandSDS-PAGEwasused.Thebandsizeis~8kDa.UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ImmunogenHumanC3ades-ArgIsotypeMouseIgG1SpeciesHumanAliasAcylationstimulatingprotein,ASPGenename:C3PositiveControlActivatedhumanserumorpurifiedhumanC3adesArgproteinNegativeControlForWesternblot,anyirrelevantproteincanbeused.StorageandstabilityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.DiseaseInfectiousdiseases,Nephrology

荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。