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Aves Labs/Dardarin/LRRK2, C-terminus (7x-253)/Purified (75-253)
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Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mLConcentration: Purified: 1 mg/mL; TC Supernatant: Lot SpecificClonality: MonoclonalForm: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")Host Species: MouseImmunogen: Fusion protein amino acids 970-2527 (C-terminus) of human LRRK2 (also known as Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin and PARK8, accession number Q5SS00)Mouse: 89% identity (1393/1557 amino acids identical)Rat:89% identity (1392/1557 amino acids identical) 30% identity with LRRK1This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.Target Description: LRRK2 (also known as PARK8) encodes a protein with 5 putative functional domains: an N-terminal leucine-rich repeat (LRR) domain, a Roc (Ras of complex protein) domain that shares sequence homology to the Ras-related GTPase superfamily, a COR (C-terminal of Roc) domain, a mitogen-activated protein kinase kinase kinase (MAPKKK) domain, and a C-terminal WD40 repeat domain. Mutation in this gene is one of the most common causes of inherited Parkinson disease (Gandhi et al., 2008). LRRK2 was originally identified as a putative disease-causing transcript (DKFZp434H2111) within a 2.6-Mb region encompassing a locus for Parkinson disease-8 (PARK8). Northern blot analysis detected a 9-kb mRNA transcript in all tissues tested, including brain. The authors named the protein product dardarin, derived from the Basque word dardara, meaning tremor. LRRK2/dardarin is also known to positively regulate autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway and together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. LRRK2/PARK8 is also known to regulate neuronal process morphology in the intact central nervous system (CNS) and play a role in synaptic vesicle trafficking.Gene ID: LRRK2 PARK8Antibody Registry ID (RRID): AB_10675136Physical State: LiquidValidation and Application NotesMolecular Weight: >200 kDaNOTEAves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.↑ back to top

神经元标志蛋白抗体

该系列产品主要用于神经元细胞的各亚细胞结构研究,可与现有的小鼠/兔抗体进行免疫双标,反应性包括人、小鼠等多个哺乳类动物。在保证抗体特异性的前提下,部分产品可分为抗不同的氨基酸片段。该系列产品包括抗APP3/APP345/APP4/APP5/ABN/TUJ/CAT/ DCX/ER1/ER2/ER3/ER5/GAD/GAP43/MAP/NET/ NUN/NSE/ NFH / NFL / NFM / PER/ PRN / PAP/ STG / TAU / TYH的抗体。除单独的抗体提供,我们还可同时提供1/3种任意抗体组合及相应二抗的试剂盒,以更优惠的价格及便捷性以满足研究人员的不同需要。

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