首页 > Echelon > echelon-inc/4-Diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME)/10mg/I-M052-10mg

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echelon-inc/4-Diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME)/10mg/I-M052-10mg

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I-M052-2

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CatalogNo.: I-M052MW: 555.38CAS: 263016-94-0Description: Isoprenoidcompoundsareadiversegroupofnaturalproductswhichareessentialcomponentsinallcells.Isoprenoidsarebiosynthesizedfromthesimpleprecursorsisopentenyldiphosphate(IPP)anddimethylallyldiphosphate(DMAPP).Eukaryotes,fungi,andsomegram-positivebacteriaproduceIPPthroughthemevalonate(MVA)pathwaywhereasgram-negativeandsomegram-positivebacteriautilizethenon-mevalonateor2-C-methyl-D-erythritol-4-phosphate(MEP)pathway.4-Diphosphocytidyl-2-C-methyl-D-erythritol(CDP-ME)isanintermediateinthenon-mevalonatepathway.ItisformedfromMEPbyCDPMESynthaseandphosphorylatedatthe2-positionbyCDPMEkinasetoCDP-MEP.Storage-20°Corbelow.FeaturedinPublications:1)Bernal,C.,E.Mendez,etal.(2005)."Aspectrophotometricassayforthedeterminationof4-diphosphocytidyl-2-C-methyl-d-erythritolkinaseactivity."AnalBiochem340(2):245-51.2)Tang,M.,S.I.Odejinmi,etal.(2011)."Identificationofnovelsmallmoleculeinhibitorsof4-diphosphocytidyl-2-C-methyl-d-erythritol(CDP-ME)kinaseofGram-negativebacteria."Bioorganic&MedicinalChemistry19(19):5886.3)Perez-Gil,J.,M.Bergua,etal.(2010)."CloningandfunctionalcharacterizationofanenzymefromHelicobacterpylorithatcatalyzestwostepsofthemethylerythritolphosphatepathwayforisoprenoidbiosynthesis."BiochimicaetBiophysicaActa(BBA)-GeneralSubjects1800(9):919.

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