首页 > Echelon > echelon-inc/1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP)/10mg/I-M055-10mg

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echelon-inc/1-Hydroxy-2-methyl-2-buten-4-yl 4-diphosphate (HDMAPP)/10mg/I-M055-10mg

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I-M055-2

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CatalogNo.: I-M055MW: 313.18CAS: 396726-03-7Description: Isoprenoidcompoundsareadiversegroupofnaturalproductswhichareessentialcomponentsinallcells.Isoprenoidsarebiosynthesizedfromthesimpleprecursorsisopentenyldiphosphate(IPP)anddimethylallyldiphosphate(DMAPP).Eukaryotes,fungi,andsomegram-positivebacteriaproduceIPPthroughthemevalonate(MVA)pathwaywhereasgram-negativeandsomegram-positivebacteriautilizethenon-mevalonateor2-C-methyl-D-erythritol-4-phosphate(MEP)pathway.1-Hydroxy-2-methyl-2-buten-4-yl4-diphosphate(HDMAPPorHMBPP)isanintermediateinthenon-mevalonatepathwayandisbiosynthesizedfrom2-C-Methyl-D-erythritol2,4-cyclophosphate(cMEPP)byIspG(GcpE).ItisthesubstrateforIspH(LytB)yieldingIPPandDMAPP.Inaddition,HDMAPPisthemostpotentVγVδT-cellactivatoridentified.Providedasthetris-ammoniumsaltStorage-20°Corbelow.FeaturedinPublications1)deBarros,A.,M.Chaves-Ferreira,etal.(2011)."CD70–CD27interactionsprovidesurvivalandproliferativesignalsthatregulateTcellreceptor-drivenactivationofhumanγδperipheralbloodlymphocytes."EuropeanJournalofImmunology41(1):195.2)Spencer,C.T.,G.Abate,etal.(2008)."OnlyaSubsetofPhosphoantigen-Responsiveγ9δ2TCellsMediateProtectiveTuberculosisImmunity."TheJournalofImmunology181(7):4471-4484.3)Moens,E.,M.Brouwer,etal.(2011)."IL-23RandTCRsignalingdrivesthegenerationofneonatalVγ9Vδ2TcellsexpressinghighlevelsofcytotoxicmediatorsandproducingIFN-gammaandIL-17."JLeukocBiol89(5):743-52.

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