产品说明
CatalogNo.: B-0041MW: 373.83Purity: 98%CAS: 1502027-70-4Acidceramidase(aCDase)isalysosomalamidasewhichhydrolyzestheacylchainfromceramidesformingsphingosinewhichissubsequentlyphosphorylatedtothebioactivelipidsphingosine1-phosphate.aCDaseisupregulatedinmanycancertypessuchasmelanoma,prostate,head,neck,andcoloncancers.ARN14988isapotentinhibitorofaCDaseinvitro(IC50=12nM)andinA375melanomacells(IC50=1.5uM).ARN14988isweaklycytotoxicbyitself,butshowsasynergysticeffectwithsomecommonanti-cancerdrugs(5-Fluorouracil,vemurafinib,andtaxol)inproliferativeG361cells.Storage-20°CorbelowReferencesN.Realini,etal.“AcidCeramidaseinMelanoma:expression,localization,andeffectsofpharmacologicalinhibition”J.Biol.Chem.,2016,291,2422-2434.
Echelon产品线
★合成磷脂、磷酸肌醇、鞘脂及其衍生物 |
★脂蛋白质相互作用工具 |
★脂质含量检测试剂盒 ★脂质相关生物酶活性检测，抑制剂筛选试剂盒 |
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