产品说明
CatalogNo.: B-0043MW: 381.42CAS: 1402830-75-4Ceramidesarebioactivesphingolipidswhichinduceapoptosisincells.Ceramidases(CDase),whichhydrolyzethefattyacidchain,keepceramidelevelsincheckandhavebeenproposedasatargetforsmall-moleculeinhibitorsforanti-cancertherapy.Ceranib-2inhibitscellularCDaseactivitywithanIC50=28uMinSKOV3cellsanddoesnotshowsignificantcytotoxityupto100uM.IncubationsofSKOV3cellswithCeranib-2resultedinanincreaseinallceramidespeciesandadose-dependantdecreaseinsphingosineandS1P.Ceranib-2suppressedtumorgrowthinamousemodelwithsubcutaneousJCcelltumors.Storage-20°Corbelow.References1)J.MDraper,etal.“DiscoveryandEvaluationofInhibitorsofHumanCeramidase”Mol.CancerTher.2011,10,2052-20612)H.S.Vethakanraj,etal.“Targetingceramidemetabolicpathwayinducesapoptosisinhumanbreastcancercelllines”Biophys.Biochem.Res.Commun.2015,464,833-839.
Echelon产品线
★合成磷脂、磷酸肌醇、鞘脂及其衍生物 |
★脂蛋白质相互作用工具 |
★脂质含量检测试剂盒 ★脂质相关生物酶活性检测，抑制剂筛选试剂盒 |
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