首页 > Echelon > Echelon/VPC 23019 (S1P1/3 Antagonist)/10 mg/B-0061

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Echelon/VPC 23019 (S1P1/3 Antagonist)/10 mg/B-0061

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B-0061

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Sphingosine-1-phosphate (S1P) is a versatile signaling molecule, which is produced by phosphorylation of sphingosine by two distinct sphingosine kinases, SphK1 and SphK2. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation, motility, survival, and has a role in regulation cell shape and Ca2+ homeostasis. VPC23019, an analog of FTY720 (Fingolimod, Gilenya), is a potent anatagonist of the S1P1 & S1P3 receptors. VPC23019 will inhibit the migration of various types of cancer cells.References1) M. D. Davis, J. J. Clemens, T. L. Macdonald, et al. “Sphingosine 1-phosphate analogs as receptor antagonists.” The Journal of Biological Chemisty, 280 (2005), 9833-9841.2) R.J. Watters, H-G. Wang, et al. “Targeting Sphingosine-1-Phosphate Receptors in Cancer” Anticancer Agents Med Chem., 11 (2011), 810-817.CategoriesBiochemical ReagentsFilterInhibitor, SphingolipidCAS Number449173-19-7Molecular FormulaC17H29N2O5PMolecular Weight (g/mol)372.18Storage-20 °C or below

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