产品说明
CatalogNo.: B-0721MW: 387.5Purity: 99%CAS: 943722-28-9Description: FTY720Pisthebioactiveformofthenovelimmunosuppressivedrugfingolimod(FTY720).FTY720isconvertedtoFTY720Pbysphingosinekinaseandthe(S)-isomeractsasanagoNISTtofourS1Preceptors(S1P1,3,4,5)withIC50sof2.1,5.9,23and2.2nMrespectively.TheRisomerbindswith5-10foldloweraffinity.FTY720Pimprovesthesurvivalofneonatalratoligodendrocytes,regulatesoligodendrocyteProgenitorcellsdifferentiation,promotesastrocytemigrationviaextracellularsignal-regulatedkinase(ERK)signaling.RecentlypublishedresultsindicateinvolvementofFTY720Pincompleteviralclearanceofpersistentinfectioncausedbyclone13oflymphoticchoriomeningitisvirus(LCMV).Storage:-20°CorbelowRelatedProducts:FTY720(B-0720)Sphingosine1-Phosphate(S1P)(S-2000)S1PELISA(K-1900)
Echelon产品线
★合成磷脂、磷酸肌醇、鞘脂及其衍生物 |
★脂蛋白质相互作用工具 |
★脂质含量检测试剂盒 ★脂质相关生物酶活性检测，抑制剂筛选试剂盒 |
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