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Kerafast/Anti-ADAM28 (mouse), Extracellular Domain Antibody/EHS012/100uL
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ThisrabbitIgGpolyclonalantibodywasgeneratedagainsttheentireectodomainofADAM28includingtheEGFrepeatfusedtotheFcdomainofhumanIgGandisspecificfortheextracellulardomainofmouseADAM28.TheADAM(ADisintegrinAndMetalloproteaseDomain)familyisauniquegroupofproteinsthathastheABIlitytocleaveorshedextracellularportionsoftransmembraneproteins.Inaddition,ADAMsareinvolvedincell-cellandcell-matrixinteractions(e.g.,fertilization,muscledevelopmentandneurogenesis).Basedonsequenceidentity,ADAM28ismorecloselyrelatedtosnakevenommetalloproteases(SVMPs)thantopresentlyknownADAMs.NorthernblotanalysisrevealedADAM28isexpressedintheepididymis,suggestingapossIBLeroleinspermmaturation,andinthelung.MatureADAM28ispresumedtobecatalyticallyactiveandfoundmainlyonthecellsurface.FromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.SpecificationsAnti-ADAM28(mouse),ExtracellularDomainAntibodyProductType: AntibodyAccessionID: AF153350Antigen: GST-ADAM28CytoplasmicDomainMolecularWeight: ~100kDaIsotype: IgGClonality: PolyclonalReactivity: MouseImmunogen: EntireectodomainofmouseADAM28includingtheEGFrepeatfusedtotheFcdomainofhumanIgG1SpeciesImmunized: RabbitEpitope: ExtracellulardomainPurificationMethod: Serum,notpurifiedTestedApplications: WB(1:500),onlyonnon-reducedsamples(noDTTorBME)Storage: -80CShipped: DryiceADAM28(mouse),CytoplasmicDomainAntibodyAntigenName:GST-ADAM28CytoplasmicDomainAccessionID:AF153350MolecularWeight:~100kDaImmunoglobulinIsotype:IgGClonality:PolyclonalSpeciesReactivity:MouseTypeofImmunogen:EntireectodomainofmouseADAM28includingtheEGFrepeatfusedtotheFcdomainofhumanIgG1Epitope:ExtracellulardomainSpeciesImmunized:RabbitPurificationMethod:Serum,notpurifiedTestedApplications:WB(1:500),onlyonnon-reducedsamples(noDTTorBME)StorageTemperature:-80CShipped:DryiceFindthebestADAMAntibodyforyourresearch:AntibodySpeciesReactivitySpecificityADAM9HumanCytoplasmicDomainADAM9MouseCytoplasmicDomainADAM12MouseCytoplasmicDomainADAM15HumanCytoplasmicDomainADAM15MouseCytoplasmicDomainADAM15HumanExtracellularDomainADAM15MouseDisintegrinDomainADAM17MouseCytoplasmicDomainADAM17MouseProdomainADAM19MouseCytoplasmicDomainADAM28MouseCytoplasmicDomainADAM28MouseExtracellularDomainSNX9MouseCytoplasmicDomainReferencesHoward,L.;Zheng,Y.;Horrocks,M.;Maciewicz,R.A.;Blobel,C.CatalyticactivityofADAM28.FEBSLett.2001,498,82-86.Ifyoupublishresearchwiththisproduct,pleaseletusknowsowecanciteyourpaper.ResearchAntibodySpeciesReactivitySpecificityADAM9HumanCytoplasmicDomainADAM9MouseCytoplasmicDomainADAM12MouseCytoplasmicDomainADAM15HumanCytoplasmicDomainADAM15MouseCytoplasmicDomainADAM15HumanExtracellularDomainADAM15MouseDisintegrinDomainADAM17MouseCytoplasmicDomainADAM17MouseProdomainADAM19MouseCytoplasmicDomainADAM28MouseCytoplasmicDomainADAM28MouseExtracellularDomainSNX9MouseCytoplasmicDomainProviderFromthelaboratoryofCarlP.Blobel,MD,PhD,HospitalforSpecialSurgery.ReferencesHoward,L.;Zheng,Y.;Horrocks,M.;Maciewicz,R.A.;Blobel,C.CatalyticactivityofADAM28.FEBSLett.2001,498,82-86.Ifyoupublishresearchwiththisproduct,pleaseletusknowsowecanciteyourpaper.

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