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Descriptionalpha-2-Macroglobulin Polyclonal Antibody – Affinity PurifiedAffinity’s alpha-2-Macroglobulin Polyclonal Antibody – Affinity Purified is the highest level of our alpha-2-Macroglobulin antibody family. During the Antigen Affinity Purification process the IgG has had any non-specific immunoglobulin fraction eliminated which enriches the specificity of the remaining immunoglobulin towards the target antigen. The result is a very high-purity product with a substantially higher titre than whole or purified IgG. Our alpha-2-Macroglobulin Polyclonal Antibody – Affinity Purified is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v) and is intended for applications such as immunoblotting, immunostaining of cells and several types of immunoassays where the higher signal-to-noise ratio achieved with this enriched product is required.Product Code: GAA2M-APRetail Product Size: 0.5mg vialHost Animal: Goat Anti-Human alpha-2-Macroglobulin Polyclonal Antibody – Affinity PurifiedSpecies Cross Reactivity: View ChartProduct Datasheet: alpha-2-macroglobulin A2M Polcylonal Antibody, affinity purified anti-human goat IgGDescription of Alpha 2-MacroglobulinAlpha 2-Macroglobulin (A2M) is a large proteinase inhibitor molecule of 718,000 daltons, consisting of 4 identical subunits of 185,000 each. Produced in hepatocytes and macrophages, plasma concentrations of A2M are typically 2 uM in adults, and as high as 6 uM in childhood. A2M has the ability to inhibit most enzymes from the serine, metallo, cysteine and aspartate subclasses. It is not a member of the SERPIN family of inhibitors but belongs to a class of proteins that include pregnancy zone protein (PZP) and the complement proteins C3, C4 and C5. These proteins contain regions of conserved sequence as well as one or more internal beta-cysteinyl-gamma-glutamyl thiolester bonds, which in the case of A2M are susceptible to cleavage by enzymes or by nucleophilic compounds such as methylamine or ammonium ions. Although the precise nature of the interactions is as yet unknown, it is generally thought that cleavage of a bait region within the A2M molecule by an enzyme leads to a conformational change, which then traps and/or covalently binds the enzyme1,2. The active site of the trapped enzyme is usually still intact and able to cleave small substrates, but is inaccessible to larger natural substrates. The conformational change induced also exposes receptor-binding regions within the molecule, which may be important in the clearance of A2M-enzyme complexes from the circulation. It is thought that the main role of A2M in vivo is that of a “backup” inhibitor and scavenger of proteinases in blood and in tissues3,4, but it has also been reported to participate in other physiological processes, including regulation of immune function1,2.References and ReviewsSalvesen G, Pizzo SV; Proteinase Inhibitors: α-Macroglobulins, Serpins and Kunins; in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 241-258, J.B. Lippincott Co., Philadelphia PA, USA, 1994.Barrett J; α2Macroglobulin; Methods in Enzymology, 80, pp 737-754, 1981Larsson LJ, Neuenschwander DE, Strickland DK; Reaction of Proteinases with α2Macroglobulin: Evidence for Alternate Reaction Pathways in the Inhibition of Trypsin; Biochemistry 28, pp 7636-7643, 1989.Schmidt B, Mitchell L, Ofosu FA, Andrew M; α2Macroglobulin is an Important Progressive Inhibitor of Thrombin in Neonatal and Infant Plasma; Thromb Haemostas 62, pp 1074-1077, 1989.Hoogendoorn H, Toh CH, Nesheim ME, Giles AR; α2Macroglobulin Binds and Inhibits Activated Protein C; Blood 78, pp2283-2290, 1991.
Affinity Biologics生产针对凝血,止血和纤维蛋白溶解相关蛋白的全系列多克隆抗体。我们的多克隆抗体家族有多种形式。完整或纯化的IgG,亲和纯化的IgG,辣根过氧化物酶偶联,异硫氰酸荧光素(FITC)偶联和生物素偶联。所有与凝血,止血和纤维蛋白溶解相关蛋白以及缺乏因子的血浆产品有关的Affinity Biologicals多克隆抗体均在内部采购,并根据ISO13485医疗设备质量保证标准生产。
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