Human IFN Alpha I (Alpha 17)Home / Products / Proteins / Interferons / Human IFN Proteins / Human IFN Alpha I (Alpha 17)Product Features:Human IFN Alpha 17 recombinant protein expressed in E.coliExpression induced by viral infectionEncoding gene IFNA17 OrderingCatalog No. Pack Size Price Quantity 11150-1 1 x 105 units$280.00 SpecificationsTech Info / DataCitationsDocumentationSpecificationsFormulationSupplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)Molecular Weight19.3 kDaSourcecDNA obtained from human leukocyte mRNA expressed in E.coliPurity> 95% by SDS-PAGE stained by Coomassie BlueBioactivityMeasured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)StorageFor retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cyclesSynonymsHu-IFN-α17Accession NumberV00532 Tech Info / DataApplication Note:A Comparison of the Binding of Interferon Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link) Background:Recombinant Human Interferon Alpha I (alpha 17) obtained from human leukocyte mRNA expressed in E.coli.IFN alpha 17 is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family.  The Type I IFN family has antiviral, anti-proliferative and natural killer cell activities. Citations4 Citations:Smith, et al. (2019). Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Science Advances, 14 pgs. PMID: 31309143. (link)Reynolds, et al. (2019). Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles. Arthritis Research & Therapy, 12 pgs. PMID: 31200750. (link)Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)Kang, Dong-Chul, et al. (2004). Expression Analysis and Genomic Characterization of Human Melanoma Differentiation Associated Gene-5, mda-5: a Novel Type I Interferon-Responsive Apoptosis-Inducing Gene. Oncogene, 12 pgs. PMID: 14676839. (link) Documentation 11150-1 Certificate of Analysis (CoA) SDS Human IFN Alpha I (Alpha 17) Titration in A549