DescriptionAdditional informationTechnical informationDownloadReferencesRelated productsInformation requestDescriptionThe Gag protein is the major structural protein required for virus assembly. It is synthesized as a polyprotein in the cytosol of an infected cell and contains four functional segments: Matrix (MA), Capsid (CA), Nucleocapsid (NC), and p6. The NC region is flanked by two “spacer” segments, denoted SP1 and SP2. The polyprotein is all alpha helical, except the NC region, which is composed of two RNA interacting zinc knuckle domains.Human immunodeficiency virus (HIV) and other primate lentiviruses assemble at the plasma membrane and are released by budding from the cell surface. This mode of assembly allows the viral capsid to acquire a host cell-derived lipid envelope which protects it from the environment. HIV-1 assembly is controlled primarily by the Gag protein. Gag encodes the capsid proteins (group specific antigens), which are the core structural proteins of HIV. HIV Gag protein is encoded by the HIV gag gene, HXB2 nucleotides 790-2292. The precursor is the p55 myristoylated protein, which is processed to p17 (MAtrix), p24 (CApsid), p7 (NucleoCapsid), and p6 proteins, by the viral protease (PR). Gag associates with the plasma membrane, where virus assembly takes place. The 55-kDa Gag precursor is called assemblin to indicate its role in viral assembly.Additional informationSize50 µgApplicationClinical diagnostics| Life SciencesProduct typeReagents for researchReagent typeRecombinant proteinCategoryHIVSubcategoryGag polyproteinTechnical informationAccession numberGenBank AAD39400Uniprot Q9WPY4Size50 µgExpression systemE.coliTagHis- taggedPurity>90%FormLyophilized with 1% glycerol.Tested applicationSDS-PAGE, WBSolubilityThe protein should be reconstituted in apirogenic sterile water or 1X PBSShipping/storage conditionsShipped at RT The lyophilized protein is stable for 24 months if stored at -20°C. Thereconstituted solution has to be used immediately.Avoid freeze-thaw cycles.UsageFor Laboratory Research Use OnlyDownloadUniProt databaseDatasheet References#tab-title-references{ display: none; }Related productsRecombinant SIV GagRecombinant SIV Gagisa full length protein produced in E.coli. SIV Gag protein is an env gene derived from a primary human immunodeficiency virustype 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. The SIV Gag protein is a molecule of 55 KDa.REP0058Rabbit Anti HIV-1 p24p24 protein is the major core protein of HIV virus particle and has been suggested as a specific target for antiviral strategies. The anti p24 polyclonal antibody would be useful for detect p24 protein as a useful tool on HIV-1 reserch. Polyclonal anti p24 antibody is designed for the detection of p24 core antigen in human serum or plasma from infected individuals as well as in cell culture supernatant.ANT0033Mouse Anti HIV-I p24 (Clone 4)HIV-1 Gag p24 antigen is a capsid protein that constitutes the core of HIV-I. p24 protein is detectable starting from the early stage of AIDS virus infection, for this reason it is an interesting marker for disease progression in infected patients. Monoclonal anti p24 antibody clone 4 is designed for the detection of p24 core antigen in human serum or plasma from infected individuals as well as in cell culture supernatant.ANT0061Mouse Anti HIV-I p24 (Clone 2)HIV-1 Gag p24 antigen is a capsid protein that constitutes the core of HIV-I. p24 protein is detectable starting from the early stage of AIDS virus infection, for this reason it is an interesting marker for disease progression in infected patients. Monoclonal anti p24 antibody clone 4 is designed for the detection of p24 core antigen in human serum or plasma from infected individuals as well as in cell culture supernatant.ANT0068Recombinant p24Recombinant p24 is a 24 kDa, full length protein produced in E. coli.REP0011Recombinant p24 BIOTINRecombinant p24 is a 24 kDa, full-length protein produced in E. coli and conjugated with NHS BiotinREP0024Information request Name * Last name * Email * Message I give my consent to direct marketing activities, including newsletters, in accordance with the Privacy Policy.I confirm that I have read the Privacy Policy, and I agree to the processing of my personal data..form-1{ font-size:14px; display: inline-block; }.form-1 textarea{ height:80px; }.textwidget input{ width: 155px; }input[type="checkbox"]{ width: 15px !important; }×