DescriptionAdditional informationTechnical informationDownloadReferencesRelated productsInformation requestDescriptionFKBP12 is notable in humans for binding the immunosuppressant molecule tacrolimus (originally designated FK506), which is used in treating patients after organ transplant and patients suffering from autoimmune disorders.[3] Tacrolimus has been found to reduce episodes of organ rejection over a related treatment, the drug ciclosporin, which binds cyclophilin.[4] Both the FKBP-tacrolimus complex and the cyclosporin-cyclophilin complex inhibit a phosphatase called calcineurin, thus blocking signal transduction in the T-lymphocyte transduction pathway.[5] This therapeutic role is not related to prolyl isomerase activity.Additional informationSize100 µgApplicationClinical diagnostics| Life SciencesProduct typeReagents for researchReagent typeRecombinant proteinCategoryCyclophilinsTechnical informationAccession numberUniProtKB/Swiss-Prot: P62942.2OrganismHumanSize100 µgExpression systemE.coliTagHIS taggedPurity>99%FormLiquid, 50mM Hepes pH 8.0, 150mM NaCl, 0,5mM EDTA, 1mM sodium azideTested applicationSDS-PAGEShipping/storage conditionsShipped at -20°C. The protein is stable for 12 months if stored at -80°C. Avoid repeated freeze/thaw cycles.UsageFor Laboratory Research Use OnlyDownloadNCBI databaseDatasheet References#tab-title-references{ display: none; }.related_prod_tab{ display:none; }Information request Name * Last name * Email * Message I give my consent to direct marketing activities, including newsletters, in accordance with the Privacy Policy.I confirm that I have read the Privacy Policy, and I agree to the processing of my personal data..form-1{ font-size:14px; display: inline-block; }.form-1 textarea{ height:80px; }.textwidget input{ width: 155px; }input[type="checkbox"]{ width: 15px !important; }×