BIOLOGICAL INFORMATIONDescriptionOrexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons. Orexin B stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B.ApplicationMelanocortinNoteFor research only, not for human use!CHEMICAL INFORMATIONCAT No.ONP10570CAS No.202801-92-1NameOrexin B, rat, mouseChemical NameOrexin-B,-rat,-mousePurity≥98%SynonymsN/AFormulaC126H215N45O34SMolecular Weight2936.4One Letter CodeRPGPPGLQGRLQRLLQANGNHAAGILTM-NH2Three Letter CodeARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2SMILESCCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(CC1=CNC=N1)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C2CCCN2C(=O)C3CCCN3C(=O)CNC(=O)C4CCCN4C(=O)C(CCCNC(=N)N)NInChI KeyRLVZFBVFVIDDPQ-GWQFQBPDSA-NSourceSyntheticFormDry PowderColorWhiteSolubilityN/ASHIPPING & STORAGEStorage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.ShippingIce PackStability≥ 2 yearsREFERENCES & CITATIONS1.Sakurai, T. et al. Cell 92, 573 (1998) 2.Sutcliffe, JG. De Lecea L. Nat. Rev. Neurosci. 3, 339 (2002)3.Schwartz, M. et al. Nature Med. 4, 385 (1998) DOCUMENTATIONSCOAData sheetMSRP-HPLCMSDSHandling InstructionPROMOTIONS & EVENTS