提醒:代购产品,无质量问题不接受退换货,下单前请仔细核对信息。下单后请及时联系客服 核对商品价格,订单生效后再付款。
ImmunoVision/SMA-3000/1000 units/SMA-3000
价格:

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号:
品牌:
会员服务:
尊享会员价
贵宾专线
运费优惠
闪电退款
福利优惠
上门换新
友情提示
以上价格仅为参考,请联系客服询价。
免费咨询热线
4000-520-616
产品说明
Product Name:   Smith (Sm) AntigenDescription:Sm antigen is a non-histone nuclear protein composed of several polypeptides of differing molecular weights. They include B (26 kD), B"(27 k D), and D (13 kD). The principle reactivity has been shown to reside in the B, B’, and D polypeptides (3). Anti-Sm autoantibodies were described originally as precipitating autoantibodies in sera of patients with Systemic Lupus Erythematosus (1). Anti-Sm antibodies are also usually accompanied by antinuclear ribonucleoprotein (nRNP) antibodies (2). The U1 RNP particle has both Sm and RNP binding specificities. The difference is that the RNP particles bound by U2, U4/6 and U5 are bound by anti-Sm autoantibodies, but not by anti-nRNP autoantibodies. Autoantibodies against the Sm antigen precipitate the U1, U2, U4/6, and U5, small nuclear RNAs (4). The Sm antigen is involved in normal post-transcriptional, premessenger RNA processing to excise introns (5). It has been demonstrated that the Sm antigenicity is both RNase and DNase resistant and partially resistant to tryptic digestion (6). Autoantibodies to Sm antigen have been observed in 15 to 30% of SLE sera as a diagnostic marker. (7) It is thought that IgG anti-Sm correlates with Lupus disease activity and is a useful variable in predicting exacerbation and prognosis of SLE. (8) It has been reported that IgG anti-Sm is specifically detected in patients with SLE. IgM anti-Sm has rarely been detected in SLE and was recognized in other diseases (2). It has also been reported in a study of clinical significance, that the frequency of lung fibrosis and pericarditis was significantly higher in patients with IgG, IgA, and/or IgM anti-Sm (2).Product Code:CodeAmountPriceInquirySMA-30001000 units$ 550.00References:Tan EM, Kunkel HG. “Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus.” J Immunol Vol 96: 1966, pg 464-471.Yasuma M, Takasaki Y, Matsumoto K, et al. “Clinical Significance of IgG Anti-Sm Antibodies in Patients with Systemic Lupus Erythematosus.” The J of Rheumatology Vol 17: 1990, pg 469-475.James JA, Harley JB. “Sequential Epitopes of an Sm B/B’ Protein” American College of Rheumatology 55th Annual Scientific Meeting, Boston, MA 1991.Lerner MR, & Steitz JA “Antibodies to Small Nuclear RNAs Complexed with Proteins are Produced by Patients with Systemic Lupus Erythematosus” Proc Natl Acad Sci Vol 76: 1979, pg 5495-5499.Yang VW, Lerner MR, Steitz JA & Flint SJ. “A Small Nuclear Ribonucleoprotein is Required for Splicing of Adenoviral Early RNA Sequences.” Proc Natl Acad Sci USA, Vol 78: 1981, pg 1371-1375.Schrier WH, Reddy R and Busch H. “Identification of An Antigenic Protein Recognized by Anti-Sm Autoantibody.” Cell Biology International Reports Vol 6: 1982.Tan EM. “Special Antibodies for the Study of Systemic Lupus Erythematosus.” Arthritis Rheum Vol 25: 1982, pg 753-756.Pollard KM, Tan EM. “Purification of the Sm Nuclear Autoantigen, Detection and Clinical Significance of IgM Antibody.” Clin Exp Immunol Vol 60: 1985, pg 586-596Specifications:    SMA-3000Certificate of Analysis: 60256030611861496190

ImmunoVision 自 1985 年以来一直为自身免疫试剂领域提供原料,自身免疫市场的领导者,是 ERBA 曼海姆集团一部分。是具有卓越的自身免疫抗原、自身免疫抗体,专业的自身免疫研究团队。