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Tocris/IDE 1/4015/50/50 mg

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Tocris Bioscience

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4015/50

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4000-520-616

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Description:InducesdefinitiveendodermformationinmouseandhumanESCs

ChemicalName:1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoicacid

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inducesdefinitiveendodermformationinmouseandhumanembryonicstemcells(ESCs)(EC₅₀=125nM).ThoughttoactivatetheTGF-βsignalingpathway;inducesSmad2phosphorylationandincreaseslevelsofNodalexpression.

LicensingInformation

SoldforresearchpurposeunderlicensefromHarvardUniversity.

CompoundLibraries

IDE1isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	306.31
Formula	C₁₅H₁₈N₂O₅
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1160927-48-9
PubChemID	66974738
InChIKey	ABKJCDILEUEJSH-UHFFFAOYSA-N
Smiles	OC(=O)CCCCCC(=O)NN=CC1=CC=CC=C1C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	2eq.NaOH	30.63	100
	DMSO	30.63	100
	ethanol	7.66	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight306.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.26mL	16.32mL	32.65mL
5mM	0.65mL	3.26mL	6.53mL
10mM	0.33mL	1.63mL	3.26mL
50mM	0.07mL	0.33mL	0.65mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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