BiologicalActivity
Cell-permeableinducerofdefinitiveendodermformationinmouseandhumanembryonicstemcells(ESCs)(EC50=223nMforinductionofSox17expressioninESCs).ReportedtoactivateTGF-βsignalinganddownstreamSmad2phosphorylation;upregulatesNodalexpression.PromotespancreaticProgenitorcellformationinvitro,andguttubeformationinvivo.
LicensingInformation
SoldforresearchpurposeunderlicensefromHarvardUniversity.
TechnicalData
| M.Wt | 240.3 |
| Formula | C12H20N2O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1136466-93-7 |
| PubChemID | 23836158 |
| InChIKey | CVYPYYPTFNVREL-UHFFFAOYSA-N |
| Smiles | O=C(N/N=C1/CCCC1)CCCCCC(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.03 | 100 | |
| water | 4.81 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight240.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.16mL | 20.81mL | 41.61mL |
| 5mM | 0.83mL | 4.16mL | 8.32mL |
| 10mM | 0.42mL | 2.08mL | 4.16mL |
| 50mM | 0.08mL | 0.42mL | 0.83mL |
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