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Tocris/KHS 101 hydrochloride/4888/50/50 mg
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4000-520-616
Description:SelectiveinducerofneuronaldifferentiationinhippocampalneuralProgenitors
ChemicalName:N4-(2-Methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediaminehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selectiveinducerofneuronaldifferentiation;inducesneuronaldifferentiationinculturedhippocampalneuralprogenitorcells(NPCs)byinteractingwithTACC3(EC50~1μM).Suppressesastrocyteformation.Alsoinducesaccelerationofneuronaldifferentiationinthehippocampaldentategyrusinvivo.
CompoundLibraries
KHS101hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 375.92 |
Formula | C18H21N5S.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
PubChemID | 90488983 |
InChIKey | INVQHPQJFRKGIO-UHFFFAOYSA-N |
Smiles | CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 18.8 | 50 | |
ethanol | 18.8 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight375.92.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.66mL | 13.3mL | 26.6mL |
5mM | 0.53mL | 2.66mL | 5.32mL |
10mM | 0.27mL | 1.33mL | 2.66mL |
50mM | 0.05mL | 0.27mL | 0.53mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
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ProductDatasheets
CertificateofAnalysis/ProductDatasheet
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